Neuropeptide levels in discrete brain regions in the iminodipropionitrile-induced persistent dyskinesia rat model

Yoshiro Kawada, Norio Ogawa, Masato Asanuma, Akitane Mori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To clarify the role of neuropeptides in dyskinesia induced by iminodipropionitrile (IDPN), the levels of five representative neuropeptides were examined in discrete regions of the rat brain 4 weeks after intraperitoneal injection of IDPN. The five neuropeptides examined were methionine-enkephalin (Met-Enk), substance P (SP) and somatostatin, which are closely related to extrapyramidal function, and thyrotropin-releasing hormone (TRH) and cholecystokinin octapeptide (CCK-8), which are closely related to the neural mechanism of the dopamine system. IDPN pretreatment significantly increased Met-Enk in the basal ganglia but not SP or somatostatin; however, all three neuropeptide levels were increased in the hindbrain. In IDPN-treated rats, TRH and CCK-8 levels were increased in the nucleus accumbens, and the frontal cortical CCK-8 level was extremely increased. These findings, together with previous reports, suggest that neuropeptides in the basal ganglia, hindbrain and cerebral cortex play important roles in the manifestation of dyskinetic symptoms.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalRegulatory Peptides
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 5 1995

Keywords

  • Basal ganglia
  • Dyskinesia
  • Hindbrain
  • Iminodipropionitrile (IDPN)
  • Neuropeptide
  • Serotonin syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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