Neuropathological comorbidity associated with argyrophilic grain disease

Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2% to 100%. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25%) had a few Gallyas-positive tufted astrocytes, six cases (30%) had a few granular/fuzzy astrocytes, and one case (5.0%) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25% when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.

Original languageEnglish
JournalNeuropathology
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Comorbidity
Astrocytes
Progressive Supranuclear Palsy
Tauopathies
Caudate Nucleus
Putamen
Frontal Lobe
Pathology
Bipolar Disorder
Prefrontal Cortex
Psychotic Disorders
Dementia
Immunohistochemistry

Keywords

  • Argyrophilic grains
  • Four repeat tau
  • Granular/fuzzy astrocytes
  • Progressive supranuclear palsy
  • Tufted astrocytes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Yokota, O., Miki, T., Ikeda, C., Nagao, S., Takenoshita, S., Ishizu, H., ... Yamada, N. (Accepted/In press). Neuropathological comorbidity associated with argyrophilic grain disease. Neuropathology. https://doi.org/10.1111/neup.12429

Neuropathological comorbidity associated with argyrophilic grain disease. / Yokota, Osamu; Miki, Tomoko; Ikeda, Chikako; Nagao, Shigeto; Takenoshita, Shintaro; Ishizu, Hideki; Haraguchi, Takashi; Kuroda, Shigetoshi; Terada, Seishi; Yamada, Norihito.

In: Neuropathology, 2017.

Research output: Contribution to journalArticle

Yokota, O, Miki, T, Ikeda, C, Nagao, S, Takenoshita, S, Ishizu, H, Haraguchi, T, Kuroda, S, Terada, S & Yamada, N 2017, 'Neuropathological comorbidity associated with argyrophilic grain disease', Neuropathology. https://doi.org/10.1111/neup.12429
Yokota, Osamu ; Miki, Tomoko ; Ikeda, Chikako ; Nagao, Shigeto ; Takenoshita, Shintaro ; Ishizu, Hideki ; Haraguchi, Takashi ; Kuroda, Shigetoshi ; Terada, Seishi ; Yamada, Norihito. / Neuropathological comorbidity associated with argyrophilic grain disease. In: Neuropathology. 2017.
@article{05442cd3ac334a65a80e936617866ace,
title = "Neuropathological comorbidity associated with argyrophilic grain disease",
abstract = "Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8{\%} to 80{\%}. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2{\%} to 100{\%}. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25{\%}) had a few Gallyas-positive tufted astrocytes, six cases (30{\%}) had a few granular/fuzzy astrocytes, and one case (5.0{\%}) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25{\%} when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.",
keywords = "Argyrophilic grains, Four repeat tau, Granular/fuzzy astrocytes, Progressive supranuclear palsy, Tufted astrocytes",
author = "Osamu Yokota and Tomoko Miki and Chikako Ikeda and Shigeto Nagao and Shintaro Takenoshita and Hideki Ishizu and Takashi Haraguchi and Shigetoshi Kuroda and Seishi Terada and Norihito Yamada",
year = "2017",
doi = "10.1111/neup.12429",
language = "English",
journal = "Neuropathology",
issn = "0919-6544",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Neuropathological comorbidity associated with argyrophilic grain disease

AU - Yokota, Osamu

AU - Miki, Tomoko

AU - Ikeda, Chikako

AU - Nagao, Shigeto

AU - Takenoshita, Shintaro

AU - Ishizu, Hideki

AU - Haraguchi, Takashi

AU - Kuroda, Shigetoshi

AU - Terada, Seishi

AU - Yamada, Norihito

PY - 2017

Y1 - 2017

N2 - Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2% to 100%. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25%) had a few Gallyas-positive tufted astrocytes, six cases (30%) had a few granular/fuzzy astrocytes, and one case (5.0%) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25% when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.

AB - Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41.2% to 100%. Conversely, in our previous study of the frequencies of mild PSP and CBD pathologies in AGD cases, five of 20 AGD cases (25%) had a few Gallyas-positive tufted astrocytes, six cases (30%) had a few granular/fuzzy astrocytes, and one case (5.0%) had a few Gallyas-positive astrocytic plaques in the putamen, caudate nucleus and/or superior frontal gyrus. Both Gallyas-positive tufted astrocytes and Gallyas-negative tau-positive granular/fuzzy astrocytes preferentially developed in the putamen, caudate nucleus and superior frontal cortex in AGD cases, being consistent with the predilection sites of Gallyas-positive tufted astrocytes in PSP cases. Further, in AGD cases, the quantities of Gallyas-positive tufted astrocytes, overall tau-positive astrocytes, and tau-positive neurons in the subcortical nuclei and superior frontal cortex were significantly correlated with Saito AGD stage, respectively. The frequency of AGD in AD cases was reported to reach up to 25% when using four-repeat tau immunohistochemistry. Pretangles are essential pathologies in AGD; however, the Braak stage of three-repeat tau-positive NFTs, which may indicate mild AD pathology or primary age-related tauopathy, was not correlated with Saito AGD stage. Clinicians should be aware of the possibility that coexisting AGD may impact clinical and radiological features in cases of other degenerative diseases.

KW - Argyrophilic grains

KW - Four repeat tau

KW - Granular/fuzzy astrocytes

KW - Progressive supranuclear palsy

KW - Tufted astrocytes

UR - http://www.scopus.com/inward/record.url?scp=85029429142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029429142&partnerID=8YFLogxK

U2 - 10.1111/neup.12429

DO - 10.1111/neup.12429

M3 - Article

JO - Neuropathology

JF - Neuropathology

SN - 0919-6544

ER -