Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

Yoshinori Itoh, Masahiro Nishibori, Ryozo Oishi, Kiyomi Saeki

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalNeuroscience Letters
Volume48
Issue number3
DOIs
Publication statusPublished - Aug 10 1984

Fingerprint

Methamphetamine
Histamine
Histamine N-Methyltransferase
Histidine Decarboxylase
Brain
Histidine
Neurons
tele-methylhistamine

Keywords

  • histamine
  • histidine
  • locomotor activity
  • methamphetamine
  • metoprine
  • mouse
  • tele-methylhistamine
  • α-fluoromethylhistidine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice. / Itoh, Yoshinori; Nishibori, Masahiro; Oishi, Ryozo; Saeki, Kiyomi.

In: Neuroscience Letters, Vol. 48, No. 3, 10.08.1984, p. 305-309.

Research output: Contribution to journalArticle

Itoh, Yoshinori ; Nishibori, Masahiro ; Oishi, Ryozo ; Saeki, Kiyomi. / Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice. In: Neuroscience Letters. 1984 ; Vol. 48, No. 3. pp. 305-309.
@article{016d353afe9d455695c8c769c501869e,
title = "Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice",
abstract = "Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.",
keywords = "histamine, histidine, locomotor activity, methamphetamine, metoprine, mouse, tele-methylhistamine, α-fluoromethylhistidine",
author = "Yoshinori Itoh and Masahiro Nishibori and Ryozo Oishi and Kiyomi Saeki",
year = "1984",
month = "8",
day = "10",
doi = "10.1016/0304-3940(84)90055-7",
language = "English",
volume = "48",
pages = "305--309",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

AU - Itoh, Yoshinori

AU - Nishibori, Masahiro

AU - Oishi, Ryozo

AU - Saeki, Kiyomi

PY - 1984/8/10

Y1 - 1984/8/10

N2 - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

AB - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

KW - histamine

KW - histidine

KW - locomotor activity

KW - methamphetamine

KW - metoprine

KW - mouse

KW - tele-methylhistamine

KW - α-fluoromethylhistidine

UR - http://www.scopus.com/inward/record.url?scp=0021166791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021166791&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(84)90055-7

DO - 10.1016/0304-3940(84)90055-7

M3 - Article

C2 - 6541326

AN - SCOPUS:0021166791

VL - 48

SP - 305

EP - 309

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -