TY - JOUR
T1 - Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice
AU - Itoh, Yoshinori
AU - Nishibori, Masahiro
AU - Oishi, Ryozo
AU - Saeki, Kiyomi
N1 - Funding Information:
in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture, Japan.
PY - 1984/8/10
Y1 - 1984/8/10
N2 - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.
AB - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.
KW - histamine
KW - histidine
KW - locomotor activity
KW - methamphetamine
KW - metoprine
KW - mouse
KW - tele-methylhistamine
KW - α-fluoromethylhistidine
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U2 - 10.1016/0304-3940(84)90055-7
DO - 10.1016/0304-3940(84)90055-7
M3 - Article
C2 - 6541326
AN - SCOPUS:0021166791
VL - 48
SP - 305
EP - 309
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -