Abstract
Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.
| Original language | English |
|---|---|
| Pages (from-to) | 305-309 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 10 1984 |
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Keywords
- histamine
- histidine
- locomotor activity
- methamphetamine
- metoprine
- mouse
- tele-methylhistamine
- α-fluoromethylhistidine
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice. / Itoh, Yoshinori; Nishibori, Masahiro; Oishi, Ryozo; Saeki, Kiyomi.
In: Neuroscience Letters, Vol. 48, No. 3, 10.08.1984, p. 305-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice
AU - Itoh, Yoshinori
AU - Nishibori, Masahiro
AU - Oishi, Ryozo
AU - Saeki, Kiyomi
PY - 1984/8/10
Y1 - 1984/8/10
N2 - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.
AB - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.
KW - histamine
KW - histidine
KW - locomotor activity
KW - methamphetamine
KW - metoprine
KW - mouse
KW - tele-methylhistamine
KW - α-fluoromethylhistidine
UR - http://www.scopus.com/inward/record.url?scp=0021166791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021166791&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(84)90055-7
DO - 10.1016/0304-3940(84)90055-7
M3 - Article
C2 - 6541326
AN - SCOPUS:0021166791
VL - 48
SP - 305
EP - 309
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -