Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

Yoshinori Itoh; Masahiro Nishibori; Ryozo Oishi; Kiyomi Saeki

doi:10.1016/0304-3940(84)90055-7

Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

Yoshinori Itoh, Masahiro Nishibori, Ryozo Oishi, Kiyomi Saeki

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Neuroscience Letters
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(84)90055-7
Publication status	Published - Aug 10 1984

Keywords

histamine
histidine
locomotor activity
methamphetamine
metoprine
mouse
tele-methylhistamine
α-fluoromethylhistidine

ASJC Scopus subject areas

Neuroscience(all)

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title = "Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice",

abstract = "Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.",

keywords = "histamine, histidine, locomotor activity, methamphetamine, metoprine, mouse, tele-methylhistamine, α-fluoromethylhistidine",

author = "Yoshinori Itoh and Masahiro Nishibori and Ryozo Oishi and Kiyomi Saeki",

year = "1984",

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T1 - Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

AU - Itoh, Yoshinori

AU - Nishibori, Masahiro

AU - Oishi, Ryozo

AU - Saeki, Kiyomi

PY - 1984/8/10

Y1 - 1984/8/10

N2 - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

AB - Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

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