TY - JOUR
T1 - Neurodevelopmental involvement in schizophrenia
T2 - The olfactory epithelium as an alternative model for research
AU - Cascella, Nicola G.
AU - Takaki, Manabu
AU - Lin, Sandra
AU - Sawa, Akira
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/8
Y1 - 2007/8
N2 - It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.
AB - It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.
KW - Neurodevelopment
KW - Olfactory epithelium
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=34447302836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447302836&partnerID=8YFLogxK
U2 - 10.1111/j.1471-4159.2007.04628.x
DO - 10.1111/j.1471-4159.2007.04628.x
M3 - Short survey
C2 - 17488280
AN - SCOPUS:34447302836
VL - 102
SP - 587
EP - 594
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 3
ER -