Neurodevelopmental involvement in schizophrenia: The olfactory epithelium as an alternative model for research

Nicola G. Cascella, Manabu Takaki, Sandra Lin, Akira Sawa

Research output: Contribution to journalShort survey

28 Citations (Scopus)

Abstract

It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.

Original languageEnglish
Pages (from-to)587-594
Number of pages8
JournalJournal of Neurochemistry
Volume102
Issue number3
DOIs
Publication statusPublished - Aug 1 2007
Externally publishedYes

Keywords

  • Neurodevelopment
  • Olfactory epithelium
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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