Neurodevelopmental involvement in schizophrenia: The olfactory epithelium as an alternative model for research

Nicola G. Cascella; Manabu Takaki; Sandra Lin; Akira Sawa

doi:10.1111/j.1471-4159.2007.04628.x

Neurodevelopmental involvement in schizophrenia: The olfactory epithelium as an alternative model for research

Nicola G. Cascella, Manabu Takaki, Sandra Lin, Akira Sawa

Research output: Contribution to journal › Short survey › peer-review

28 Citations (Scopus)

Abstract

It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.

Original language	English
Pages (from-to)	587-594
Number of pages	8
Journal	Journal of Neurochemistry
Volume	102
Issue number	3
DOIs	https://doi.org/10.1111/j.1471-4159.2007.04628.x
Publication status	Published - Aug 2007
Externally published	Yes

Keywords

Neurodevelopment
Olfactory epithelium
Schizophrenia

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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abstract = "It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.",

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AU - Lin, Sandra

AU - Sawa, Akira

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AB - It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.

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