Neurodevelopment in full-term small for gestational age infants: A nationwide Japanese population-based study

Akihito Takeuchi, Takashi Yorifuji, Kyohei Takahashi, Makoto Nakamura, Misao Kageyama, Toshihide Kubo, Tatsuya Ogino, Hiroyuki Doi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To investigate neurological development in small for gestational age (SGA) infants, with a focus on full-term SGA infants. Methods: We analyzed data from a large, Japanese, nationwide, population-based longitudinal survey started in 2001. We restricted the study to participants born before 42. weeks of gestation (n = 46,563). Parents were asked questions about motor and language development when the children were 2.5. years old, and about behavioral development at 5.5. years. We analyzed the relationships between SGA status and development by logistic regression. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for each outcome for full-term and preterm births, adjusting for potential infant- and parent-related confounding factors. We also calculated the population-attributable fractions to estimate the public impact of SGA births. Results: SGA full-term children were more likely to demonstrate developmental delays at 2.5. years, e.g., being unable to walk alone (OR 3.0, 95% CI: 1.7, 5.3), compose a two-phrase sentence (OR 1.5, 95% CI: 1.2, 1.8), or use a spoon to eat (OR 1.5, 95% CI: 1.1, 1.9). SGA status also had some degree of negative impacts on behavioral problems at 5.5. years among term children, e.g., being unable to listen without fidgeting (OR 1.2, 95% CI: 1.1, 1.3), or remain patient (OR 1.1, 95% CI: 1.0, 1.2). The public health impacts were comparable between full-term and preterm SGA children at 2.5. years. Conclusion: SGA is a risk factor for developmental delay, even in full-term infants, with non-negligible public health impacts.

Original languageEnglish
JournalBrain and Development
DOIs
Publication statusAccepted/In press - Jun 22 2015

Fingerprint

Small for Gestational Age Infant
Gestational Age
Odds Ratio
Confidence Intervals
Population
Public Health
Term Birth
Language Development
Premature Birth
Longitudinal Studies
Parents
Logistic Models
Parturition
Pregnancy

Keywords

  • Behavior
  • Development
  • Epidemiology
  • Growth
  • Small-for-gestational-age

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Neurodevelopment in full-term small for gestational age infants : A nationwide Japanese population-based study. / Takeuchi, Akihito; Yorifuji, Takashi; Takahashi, Kyohei; Nakamura, Makoto; Kageyama, Misao; Kubo, Toshihide; Ogino, Tatsuya; Doi, Hiroyuki.

In: Brain and Development, 22.06.2015.

Research output: Contribution to journalArticle

Takeuchi, Akihito ; Yorifuji, Takashi ; Takahashi, Kyohei ; Nakamura, Makoto ; Kageyama, Misao ; Kubo, Toshihide ; Ogino, Tatsuya ; Doi, Hiroyuki. / Neurodevelopment in full-term small for gestational age infants : A nationwide Japanese population-based study. In: Brain and Development. 2015.
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abstract = "Objective: To investigate neurological development in small for gestational age (SGA) infants, with a focus on full-term SGA infants. Methods: We analyzed data from a large, Japanese, nationwide, population-based longitudinal survey started in 2001. We restricted the study to participants born before 42. weeks of gestation (n = 46,563). Parents were asked questions about motor and language development when the children were 2.5. years old, and about behavioral development at 5.5. years. We analyzed the relationships between SGA status and development by logistic regression. Odds ratios (ORs) and 95{\%} confidence intervals (95{\%} CI) were calculated for each outcome for full-term and preterm births, adjusting for potential infant- and parent-related confounding factors. We also calculated the population-attributable fractions to estimate the public impact of SGA births. Results: SGA full-term children were more likely to demonstrate developmental delays at 2.5. years, e.g., being unable to walk alone (OR 3.0, 95{\%} CI: 1.7, 5.3), compose a two-phrase sentence (OR 1.5, 95{\%} CI: 1.2, 1.8), or use a spoon to eat (OR 1.5, 95{\%} CI: 1.1, 1.9). SGA status also had some degree of negative impacts on behavioral problems at 5.5. years among term children, e.g., being unable to listen without fidgeting (OR 1.2, 95{\%} CI: 1.1, 1.3), or remain patient (OR 1.1, 95{\%} CI: 1.0, 1.2). The public health impacts were comparable between full-term and preterm SGA children at 2.5. years. Conclusion: SGA is a risk factor for developmental delay, even in full-term infants, with non-negligible public health impacts.",
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AU - Nakamura, Makoto

AU - Kageyama, Misao

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AB - Objective: To investigate neurological development in small for gestational age (SGA) infants, with a focus on full-term SGA infants. Methods: We analyzed data from a large, Japanese, nationwide, population-based longitudinal survey started in 2001. We restricted the study to participants born before 42. weeks of gestation (n = 46,563). Parents were asked questions about motor and language development when the children were 2.5. years old, and about behavioral development at 5.5. years. We analyzed the relationships between SGA status and development by logistic regression. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for each outcome for full-term and preterm births, adjusting for potential infant- and parent-related confounding factors. We also calculated the population-attributable fractions to estimate the public impact of SGA births. Results: SGA full-term children were more likely to demonstrate developmental delays at 2.5. years, e.g., being unable to walk alone (OR 3.0, 95% CI: 1.7, 5.3), compose a two-phrase sentence (OR 1.5, 95% CI: 1.2, 1.8), or use a spoon to eat (OR 1.5, 95% CI: 1.1, 1.9). SGA status also had some degree of negative impacts on behavioral problems at 5.5. years among term children, e.g., being unable to listen without fidgeting (OR 1.2, 95% CI: 1.1, 1.3), or remain patient (OR 1.1, 95% CI: 1.0, 1.2). The public health impacts were comparable between full-term and preterm SGA children at 2.5. years. Conclusion: SGA is a risk factor for developmental delay, even in full-term infants, with non-negligible public health impacts.

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