Abstract
The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually all NC-ir TG neurons exhibited S100- immunoreactivity (-ir). In the tooth pulp, NC-ir nerve fibers were observed in the subodontoblastic and odontoblastic layers. Immunoelectron microscopic and retrograde tracing methods revealed that myelinated pulpal axons derived from the TG mostly exhibited the ir. In the periodontal ligament, bush-like endings showed NC-ir. These endings were morphologically identical to Ruffini-like endings. The present study suggests that NC-ir trigeminal primary sensory neurons have their cell bodies in the TG. Their peripheral axons are probably myelinated. Such neurons include pulpal nociceptors and low-threshold mechanoreceptors. (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 152-156 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 864 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 5 2000 |
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Keywords
- Immunohistochemistry
- Neurocalcin
- Periodontal ligament
- S100
- Tooth pulp
- Trigeminal ganglion
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neurocalcin-immunoreactive primary sensory neurons in the trigeminal ganglion provide myelinated innervation to the tooth pulp and periodontal ligament. / Ichikawa, Hiroyuki; Hidaka, Hiroyoshi; Sugimoto, Tomosada.
In: Brain Research, Vol. 864, No. 1, 05.05.2000, p. 152-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurocalcin-immunoreactive primary sensory neurons in the trigeminal ganglion provide myelinated innervation to the tooth pulp and periodontal ligament
AU - Ichikawa, Hiroyuki
AU - Hidaka, Hiroyoshi
AU - Sugimoto, Tomosada
PY - 2000/5/5
Y1 - 2000/5/5
N2 - The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually all NC-ir TG neurons exhibited S100- immunoreactivity (-ir). In the tooth pulp, NC-ir nerve fibers were observed in the subodontoblastic and odontoblastic layers. Immunoelectron microscopic and retrograde tracing methods revealed that myelinated pulpal axons derived from the TG mostly exhibited the ir. In the periodontal ligament, bush-like endings showed NC-ir. These endings were morphologically identical to Ruffini-like endings. The present study suggests that NC-ir trigeminal primary sensory neurons have their cell bodies in the TG. Their peripheral axons are probably myelinated. Such neurons include pulpal nociceptors and low-threshold mechanoreceptors. (C) 2000 Elsevier Science B.V.
AB - The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually all NC-ir TG neurons exhibited S100- immunoreactivity (-ir). In the tooth pulp, NC-ir nerve fibers were observed in the subodontoblastic and odontoblastic layers. Immunoelectron microscopic and retrograde tracing methods revealed that myelinated pulpal axons derived from the TG mostly exhibited the ir. In the periodontal ligament, bush-like endings showed NC-ir. These endings were morphologically identical to Ruffini-like endings. The present study suggests that NC-ir trigeminal primary sensory neurons have their cell bodies in the TG. Their peripheral axons are probably myelinated. Such neurons include pulpal nociceptors and low-threshold mechanoreceptors. (C) 2000 Elsevier Science B.V.
KW - Immunohistochemistry
KW - Neurocalcin
KW - Periodontal ligament
KW - S100
KW - Tooth pulp
KW - Trigeminal ganglion
UR - http://www.scopus.com/inward/record.url?scp=0034607589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034607589&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(00)02175-2
DO - 10.1016/S0006-8993(00)02175-2
M3 - Article
C2 - 10793200
AN - SCOPUS:0034607589
VL - 864
SP - 152
EP - 156
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -