Abstract
Levodopa (L-DOPA) is the most commonly used pharmacotherapy in patients with Parkinson's disease (PD), but is also associated with adverse effects during chronic use and a decreased ability to control PD as the disease progresses. Neural transplantation of dopamine-synthesizing cells is being explored as a possible alternative to L-DOPA for the treatment of PD. In a rodent model of PD, we demonstrated that neural transplantation of dopamine-releasing cells (from fetal midbrain areas) led to normalisation of striatal D1 and D2 dopamine receptors to their non-PD levels at 3 months post-transplantation, which was accompanied by near normalization of rotational behavior. Immunohistochemical evaluation showed that grafted fetal dopaminergic cells survive, synthesize and release dopamine for at least 3 months post-transplantation. Grafting of neuronal cells into the brain therefore represents a promising approach to restoring disturbed motor function characteristic of PD.
| Original language | English |
|---|---|
| Pages (from-to) | 133-138 |
| Number of pages | 6 |
| Journal | Journal of Brain Science |
| Volume | 25 |
| Issue number | 3-4 |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Neural transplantation normalizes dopaminergic dysfunction in an animal model of parkinson's disease. / Ogawa, N.; Mizukawa, K.; Nishiono, H.; Asanuma, Masato; Yamamoto, M.
In: Journal of Brain Science, Vol. 25, No. 3-4, 1999, p. 133-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neural transplantation normalizes dopaminergic dysfunction in an animal model of parkinson's disease
AU - Ogawa, N.
AU - Mizukawa, K.
AU - Nishiono, H.
AU - Asanuma, Masato
AU - Yamamoto, M.
PY - 1999
Y1 - 1999
N2 - Levodopa (L-DOPA) is the most commonly used pharmacotherapy in patients with Parkinson's disease (PD), but is also associated with adverse effects during chronic use and a decreased ability to control PD as the disease progresses. Neural transplantation of dopamine-synthesizing cells is being explored as a possible alternative to L-DOPA for the treatment of PD. In a rodent model of PD, we demonstrated that neural transplantation of dopamine-releasing cells (from fetal midbrain areas) led to normalisation of striatal D1 and D2 dopamine receptors to their non-PD levels at 3 months post-transplantation, which was accompanied by near normalization of rotational behavior. Immunohistochemical evaluation showed that grafted fetal dopaminergic cells survive, synthesize and release dopamine for at least 3 months post-transplantation. Grafting of neuronal cells into the brain therefore represents a promising approach to restoring disturbed motor function characteristic of PD.
AB - Levodopa (L-DOPA) is the most commonly used pharmacotherapy in patients with Parkinson's disease (PD), but is also associated with adverse effects during chronic use and a decreased ability to control PD as the disease progresses. Neural transplantation of dopamine-synthesizing cells is being explored as a possible alternative to L-DOPA for the treatment of PD. In a rodent model of PD, we demonstrated that neural transplantation of dopamine-releasing cells (from fetal midbrain areas) led to normalisation of striatal D1 and D2 dopamine receptors to their non-PD levels at 3 months post-transplantation, which was accompanied by near normalization of rotational behavior. Immunohistochemical evaluation showed that grafted fetal dopaminergic cells survive, synthesize and release dopamine for at least 3 months post-transplantation. Grafting of neuronal cells into the brain therefore represents a promising approach to restoring disturbed motor function characteristic of PD.
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M3 - Article
AN - SCOPUS:0033282315
VL - 25
SP - 133
EP - 138
JO - Journal of Brain Science
JF - Journal of Brain Science
SN - 1341-5301
IS - 3-4
ER -