Neural transplantation for Parkinson's disease

Isao Date, Takashi Ohmoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative source. 2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain. 3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described.

Original languageEnglish
Pages (from-to)67-78
Number of pages12
JournalCellular and molecular neurobiology
Volume19
Issue number1
DOIs
Publication statusPublished - Mar 8 1999

Keywords

  • Adrenal medulla
  • Chromaffin cell
  • Cryopreservation
  • Dopamine
  • Encapsulated cell grafting
  • Neural transplantation
  • Parkinson's disease

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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