TY - JOUR
T1 - Neural transplantation for Parkinson's disease
AU - Date, Isao
AU - Ohmoto, Takashi
N1 - Funding Information:
This work was supported in part by Grants-in-Aid 07671521 and 07457317 from the Ministry of Education, Science and Culture, Japan.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - 1. Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative source. 2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain. 3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described.
AB - 1. Neural transplantation is one promising approach for the treatment of Parkinson's disease. Fetal substantia nigra cells are a good source of dopamine, but in order to avoid ethical and immunological problems, adrenal medullary chromaffin cells have been investigated as an alternative source. 2. Grafted adrenal medullary chromaffin cells can provide dopamine as well as several neurotrophic factors that affect dopaminergic neurons in the brain. 3. We review experimental studies for application of neural transplantation techniques in Parkinson's disease, including immunological studies, cryopreservation, microvasculature, donor tissue, and direct gene delivery studies performed in our laboratory. Our clinical experience and new approach involving a polymer-encapsulated cell grafting procedure are also described.
KW - Adrenal medulla
KW - Chromaffin cell
KW - Cryopreservation
KW - Dopamine
KW - Encapsulated cell grafting
KW - Neural transplantation
KW - Parkinson's disease
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U2 - 10.1023/A:1006964507916
DO - 10.1023/A:1006964507916
M3 - Article
C2 - 10079966
AN - SCOPUS:0033036543
VL - 19
SP - 67
EP - 78
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
SN - 0272-4340
IS - 1
ER -