Neural parvalbumin and calretinin in the tooth pulp

Hiroyuki Ichikawa, Touru Deguchi, Seiji Mitani, Tadao Nakago, David M. Jacobowitz, Tomoichirou Yamaai, Tomosada Sugimoto

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Parvalbumin- and calretinin-immunoreactivities (CR-irs) were examined in the molar tooth pulp of the rat using immunohistochemical methods. CR-ir fibers were further classified based on the tachykinin-ir revealed by a double immunofluorescence method. The rat root pulp contained three types of nerve fibers; parvalbumin-ir smooth fibers, CR-ir (TK-negative) smooth fibers and CR-ir (TK-ir) varicose fibers. These fibers projected toward the roof of the pulp chamber and pulp horn without marked ramification. In the subodontoblastic layer at the roof of the pulp chamber and pulp horn, parvalbumin-ir smooth fibers repeatedly ramified and extended varicose terminals into the odontoblastic layer. CR-ir (TK-negative) smooth fibers reached the subodontoblastic layer without marked ramification and gave rise to varicose terminals that appeared to terminate within the subodontoblastic layer. On the other hand, CR-ir (TK-ir) varicose fibers proceeded to the subodontoblastic layer at the roof of the pulp chamber and pulp horn, where they ramified and penetrated the odontoblastic layer. The present study indicates that the rat tooth pulp contains myelinated parvalbumin-ir and CR-ir (TK-negative) fibers, and unmyelinated CR-ir (TK-ir) fibers, and that they project varicose terminals to the subodontoblastic and odontoblastic layers. The central projection sites of these sensory fibers have yet to be revealed.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalBrain Research
Volume647
Issue number1
DOIs
Publication statusPublished - May 30 1994

Keywords

  • Calretinin
  • Parvalbumin
  • Rat
  • Sensory nerve
  • Tachykinin
  • Tooth pulp

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Ichikawa, H., Deguchi, T., Mitani, S., Nakago, T., Jacobowitz, D. M., Yamaai, T., & Sugimoto, T. (1994). Neural parvalbumin and calretinin in the tooth pulp. Brain Research, 647(1), 124-130. https://doi.org/10.1016/0006-8993(94)91406-0