TY - GEN
T1 - Nerve regeneration by using of chitosan-silicate hybrid porous membranes
AU - Shirosaki, Yuki
AU - Hayakawa, Satoshi
AU - Osaka, Akiyoshi
AU - Santos, José D.
AU - Maurício, Ana C.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.
AB - The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.
KW - Chitosan
KW - Inorganic-organic hybrid
KW - Nerve regeneration
KW - Porous membrane
UR - http://www.scopus.com/inward/record.url?scp=84871313560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871313560&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.529-530.361
DO - 10.4028/www.scientific.net/KEM.529-530.361
M3 - Conference contribution
AN - SCOPUS:84871313560
SN - 9783037855171
T3 - Key Engineering Materials
SP - 361
EP - 364
BT - Bioceramics 24
PB - Trans Tech Publications Ltd
T2 - 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Y2 - 21 October 2012 through 24 October 2012
ER -