Nerve regeneration by using of chitosan-silicate hybrid porous membranes

Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, José D. Santos, Ana C. Maurício

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages361-364
Number of pages4
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - Jan 1 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: Oct 21 2012Oct 24 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period10/21/1210/24/12

Keywords

  • Chitosan
  • Inorganic-organic hybrid
  • Nerve regeneration
  • Porous membrane

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Shirosaki, Y., Hayakawa, S., Osaka, A., Santos, J. D., & Maurício, A. C. (2013). Nerve regeneration by using of chitosan-silicate hybrid porous membranes. In Bioceramics 24 (1 ed., pp. 361-364). (Key Engineering Materials; Vol. 529-530, No. 1). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.529-530.361