Nerve regeneration by using of chitosan-silicate hybrid porous membranes

Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, José D. Santos, Ana C. Maurício

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.

Original languageEnglish
Title of host publicationKey Engineering Materials
Pages361-364
Number of pages4
Volume529-530
Edition1
DOIs
Publication statusPublished - 2013
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: Oct 21 2012Oct 24 2012

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)10139826

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period10/21/1210/24/12

Fingerprint

Silicates
Chitosan
Membranes
Neurosurgery
Recovery
Biocompatibility
Grafts
Drying
Gels
Tissue

Keywords

  • Chitosan
  • Inorganic-organic hybrid
  • Nerve regeneration
  • Porous membrane

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shirosaki, Y., Hayakawa, S., Osaka, A., Santos, J. D., & Maurício, A. C. (2013). Nerve regeneration by using of chitosan-silicate hybrid porous membranes. In Key Engineering Materials (1 ed., Vol. 529-530, pp. 361-364). (Key Engineering Materials; Vol. 529-530, No. 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.361

Nerve regeneration by using of chitosan-silicate hybrid porous membranes. / Shirosaki, Yuki; Hayakawa, Satoshi; Osaka, Akiyoshi; Santos, José D.; Maurício, Ana C.

Key Engineering Materials. Vol. 529-530 1. ed. 2013. p. 361-364 (Key Engineering Materials; Vol. 529-530, No. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shirosaki, Y, Hayakawa, S, Osaka, A, Santos, JD & Maurício, AC 2013, Nerve regeneration by using of chitosan-silicate hybrid porous membranes. in Key Engineering Materials. 1 edn, vol. 529-530, Key Engineering Materials, no. 1, vol. 529-530, pp. 361-364, 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012, Fukuoka, Japan, 10/21/12. https://doi.org/10.4028/www.scientific.net/KEM.529-530.361
Shirosaki Y, Hayakawa S, Osaka A, Santos JD, Maurício AC. Nerve regeneration by using of chitosan-silicate hybrid porous membranes. In Key Engineering Materials. 1 ed. Vol. 529-530. 2013. p. 361-364. (Key Engineering Materials; 1). https://doi.org/10.4028/www.scientific.net/KEM.529-530.361
Shirosaki, Yuki ; Hayakawa, Satoshi ; Osaka, Akiyoshi ; Santos, José D. ; Maurício, Ana C. / Nerve regeneration by using of chitosan-silicate hybrid porous membranes. Key Engineering Materials. Vol. 529-530 1. ed. 2013. pp. 361-364 (Key Engineering Materials; 1).
@inproceedings{7f4c0c8068df4ae19d8edd16fc3cd5d3,
title = "Nerve regeneration by using of chitosan-silicate hybrid porous membranes",
abstract = "The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.",
keywords = "Chitosan, Inorganic-organic hybrid, Nerve regeneration, Porous membrane",
author = "Yuki Shirosaki and Satoshi Hayakawa and Akiyoshi Osaka and Santos, {Jos{\'e} D.} and Maur{\'i}cio, {Ana C.}",
year = "2013",
doi = "10.4028/www.scientific.net/KEM.529-530.361",
language = "English",
isbn = "9783037855171",
volume = "529-530",
series = "Key Engineering Materials",
number = "1",
pages = "361--364",
booktitle = "Key Engineering Materials",
edition = "1",

}

TY - GEN

T1 - Nerve regeneration by using of chitosan-silicate hybrid porous membranes

AU - Shirosaki, Yuki

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

AU - Santos, José D.

AU - Maurício, Ana C.

PY - 2013

Y1 - 2013

N2 - The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.

AB - The treatment of peripheral nerve injuries is still one of the most challenging tasks in neurosurgery, as functional recovery is rarely satisfactory in these patients. The concept behind the use of biodegradable nerve guides is that no foreign material should be left in place after the device has fulfilled its task, so as to spare a second surgical intervention. In a previous study, flexible and biodegradable chitosan-γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membranes exhibited better cytocompatibility in terms of osteoblastic cells than chitosan membrane. Porous chitosan hybrid membranes, derived by freeze-drying the hybrid gels, showed that the cells were attached and proliferated both on the surface and into pores. The aim of the present study was to evaluate the influence of these chitosan hybrid membranes in terms of their inflammatory response and remodeling of connective tissue during wound-healing processes before use as a periphery nerve graft. The porous chitosan hybrid membranes showed good biocompatibility and improved posttraumatic axonal regrowth and functional recovery.

KW - Chitosan

KW - Inorganic-organic hybrid

KW - Nerve regeneration

KW - Porous membrane

UR - http://www.scopus.com/inward/record.url?scp=84871313560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871313560&partnerID=8YFLogxK

U2 - 10.4028/www.scientific.net/KEM.529-530.361

DO - 10.4028/www.scientific.net/KEM.529-530.361

M3 - Conference contribution

AN - SCOPUS:84871313560

SN - 9783037855171

VL - 529-530

T3 - Key Engineering Materials

SP - 361

EP - 364

BT - Key Engineering Materials

ER -