Nerve growth factor suppresses prostate tumor growth

Mitsuhiro Goda, Saori Atagi, Keisuke Amitani, Narumi Hobara, Yoshihisa Kitamura, Hiromu Kawasaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Nerve growth factor (NGF) facilitates reinnervation of perivascular nerves that regulate vascular tone and blood flow. This study investigated whether NGF prevents tumor growth by promoting neuronal regulation of tumor blood flow. The growth rate of DU145 prostate carcinoma cells subcutaneously implanted into nude mice was significantly inhibited by subcutaneous NGF administration. Significant suppression of tumor growth continued after withdrawing NGF. NGF increased vascular smooth muscle cells in tumor tissues, but had no cytotoxic action on tumor cells in vitro. These results suggest that NGF prevents tumor growth via an indirect effect, probably innervation or maturation of the tumor neovasculature.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalJournal of Pharmacological Sciences
Volume112
Issue number4
DOIs
Publication statusPublished - Apr 16 2010

Keywords

  • Angiogenesis
  • Nerve growth factor
  • Prostate tumor growth

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Goda, M., Atagi, S., Amitani, K., Hobara, N., Kitamura, Y., & Kawasaki, H. (2010). Nerve growth factor suppresses prostate tumor growth. Journal of Pharmacological Sciences, 112(4), 463-466. https://doi.org/10.1254/jphs.09354SC