Nephrotic syndrome due to metabolic disease--special reference to diabetic nephropathy

Research output: Contribution to journalArticle

Abstract

Diabetes has become the most common single cause of end stage renal disease. Nephrotic syndrome is often manifested in the progression of diabetic nephropathy. Diabetic nephropathy has several pathways for development, such as glomerular hyperfiltration, upregulation of protein kinase C, advanced glycation end products, activation of polyol pathway, increased oxidative stress and upregulation of growth factors. Intensive control of blood pressure and the use of angiotensin converting enzyme inhibitor or angiotensin receptor blocker can protect the progression of nephropathy with nephrotic syndrome. However further studies are necessary for the clinical guidline in patients with diabetic nephropathy manifesting with nephrotic syndrome.

Original languageEnglish
Pages (from-to)1907-1913
Number of pages7
JournalNihon rinsho. Japanese journal of clinical medicine
Volume62
Issue number10
Publication statusPublished - 2004

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Metabolic Diseases
Nephrotic Syndrome
Diabetic Nephropathies
Up-Regulation
Advanced Glycosylation End Products
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Protein Kinase C
Chronic Kidney Failure
Intercellular Signaling Peptides and Proteins
Oxidative Stress
Blood Pressure

Cite this

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title = "Nephrotic syndrome due to metabolic disease--special reference to diabetic nephropathy",
abstract = "Diabetes has become the most common single cause of end stage renal disease. Nephrotic syndrome is often manifested in the progression of diabetic nephropathy. Diabetic nephropathy has several pathways for development, such as glomerular hyperfiltration, upregulation of protein kinase C, advanced glycation end products, activation of polyol pathway, increased oxidative stress and upregulation of growth factors. Intensive control of blood pressure and the use of angiotensin converting enzyme inhibitor or angiotensin receptor blocker can protect the progression of nephropathy with nephrotic syndrome. However further studies are necessary for the clinical guidline in patients with diabetic nephropathy manifesting with nephrotic syndrome.",
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