Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells

Nobuaki Okumura, Masanori Ikeda, Shinya Satoh, Hiromichi Dansako, Masaya Sugiyama, Masashi Mizokami, Nobuyuki Kato

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Hepatitis B virus (HBV) replication is controlled by liver-enriched transcriptional factors, including forkhead box protein A (FOXA) members. Here, we found that FOXA members are directly and indirectly involved in HBV replication in human hepatic cells. HBV replication was elevated in HuH-7 treated with individual FOXA members-specific siRNA. Reciprocally, the downregulation of HBV replication was observed in FOXA-induced HuH-7. However, the mechanism of downregulation is different among FOXA members at the level of HBV RNA transcription, such as precore/pg RNA and 2.1 kb RNA. In addition, FOXA1 and FOXA2 suppressed nuclear hormone receptors, such as HNF4α, that are related to HBV replication.

Original languageEnglish
Pages (from-to)1112-1118
Number of pages7
JournalFEBS Letters
Volume589
Issue number10
DOIs
Publication statusPublished - Apr 28 2015

Keywords

  • FOXA1
  • FOXA2
  • FOXA3
  • HNF3
  • Hepatitis B virus
  • Hepatitis B virus replication

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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