Abstract
The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum- specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.
| Original language | English |
|---|---|
| Pages (from-to) | 899-901 |
| Number of pages | 3 |
| Journal | Journal of Bacteriology |
| Volume | 178 |
| Issue number | 3 |
| Publication status | Published - Feb 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Immunology
Cite this
Negative regulation by FliD, FliS, and FliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium. / Yokoseki, Tatsuki; Iino, Tetsuo; Kutsukake, Kazuhiro.
In: Journal of Bacteriology, Vol. 178, No. 3, 02.1996, p. 899-901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative regulation by FliD, FliS, and FliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium
AU - Yokoseki, Tatsuki
AU - Iino, Tetsuo
AU - Kutsukake, Kazuhiro
PY - 1996/2
Y1 - 1996/2
N2 - The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum- specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.
AB - The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum- specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030032662&partnerID=8YFLogxK
M3 - Article
C2 - 8550529
AN - SCOPUS:0030032662
VL - 178
SP - 899
EP - 901
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 3
ER -