To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryoprobe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an introducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5,10,15,20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm's feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be performed using the experimental device and electrosurgical device.
|Number of pages||6|
|Journal||Acta medica Okayama|
|Publication status||Published - 2021|
- electrosurgical device
- needle tract ablation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)