Neck metastasis in patients with T1-2 supraglottic cancer

Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Sei ichiro Makihara, Misato Hirai, Yuka Gion, Kana Ikegami, Kentaro Miki, Takuma Makino, Yasuyuki Noyama, Yasutoshi Komatsubara, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70. years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.

Original languageEnglish
JournalAuris Nasus Larynx
DOIs
Publication statusAccepted/In press - Feb 12 2017

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Neck
Neoplasm Metastasis
Papillomavirus Infections
Neoplasms
Multivariate Analysis
Tongue Neoplasms
Head and Neck Neoplasms
Retrospective Studies

Keywords

  • Human papillomavirus
  • Neck metastasis
  • Prognosis
  • Sublocation
  • Supraglottic cancer

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Neck metastasis in patients with T1-2 supraglottic cancer. / Tachibana, Tomoyasu; Orita, Yorihisa; Marunaka, Hidenori; Makihara, Sei ichiro; Hirai, Misato; Gion, Yuka; Ikegami, Kana; Miki, Kentaro; Makino, Takuma; Noyama, Yasuyuki; Komatsubara, Yasutoshi; Kimura, Miyuki; Yoshino, Tadashi; Nishizaki, Kazunori; Sato, Yasuharu.

In: Auris Nasus Larynx, 12.02.2017.

Research output: Contribution to journalArticle

Tachibana, Tomoyasu ; Orita, Yorihisa ; Marunaka, Hidenori ; Makihara, Sei ichiro ; Hirai, Misato ; Gion, Yuka ; Ikegami, Kana ; Miki, Kentaro ; Makino, Takuma ; Noyama, Yasuyuki ; Komatsubara, Yasutoshi ; Kimura, Miyuki ; Yoshino, Tadashi ; Nishizaki, Kazunori ; Sato, Yasuharu. / Neck metastasis in patients with T1-2 supraglottic cancer. In: Auris Nasus Larynx. 2017.
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abstract = "Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5{\%}). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70. years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9{\%}) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.",
keywords = "Human papillomavirus, Neck metastasis, Prognosis, Sublocation, Supraglottic cancer",
author = "Tomoyasu Tachibana and Yorihisa Orita and Hidenori Marunaka and Makihara, {Sei ichiro} and Misato Hirai and Yuka Gion and Kana Ikegami and Kentaro Miki and Takuma Makino and Yasuyuki Noyama and Yasutoshi Komatsubara and Miyuki Kimura and Tadashi Yoshino and Kazunori Nishizaki and Yasuharu Sato",
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T1 - Neck metastasis in patients with T1-2 supraglottic cancer

AU - Tachibana, Tomoyasu

AU - Orita, Yorihisa

AU - Marunaka, Hidenori

AU - Makihara, Sei ichiro

AU - Hirai, Misato

AU - Gion, Yuka

AU - Ikegami, Kana

AU - Miki, Kentaro

AU - Makino, Takuma

AU - Noyama, Yasuyuki

AU - Komatsubara, Yasutoshi

AU - Kimura, Miyuki

AU - Yoshino, Tadashi

AU - Nishizaki, Kazunori

AU - Sato, Yasuharu

PY - 2017/2/12

Y1 - 2017/2/12

N2 - Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70. years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.

AB - Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age <70. years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.

KW - Human papillomavirus

KW - Neck metastasis

KW - Prognosis

KW - Sublocation

KW - Supraglottic cancer

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