Necessity is the mother of invention: An ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

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1 Citation (Scopus)

Abstract

(Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.

Original languageEnglish
Pages (from-to)1024-1025
Number of pages2
JournalChemMedChem
Volume3
Issue number7
DOIs
Publication statusPublished - Jul 14 2008

Fingerprint

Cyclin D1
Patents and inventions
Nanoparticles
Small Interfering RNA
Leukocytes
Inflammation
Colitis

Keywords

  • Cyclin D1
  • Inflammation
  • Nanoparticles
  • RNA interference
  • Systemic administration

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

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abstract = "(Figure Presented) Leukocyte-targeted delivery of siRNA in stabilized nanoparticles: This Highlight article summarizes elegantly designed targeted nanoparticles that can be administered systemically to deliver siRNA for cyclin D1 to specific leukocyte subsets. Silencing of cyclin D1 in this way can reverse experimentally induced colitis in mice.",
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