Necessity for reassessment of patients with serogroup 2 hepatitis C virus (HCV) and undetectable serum HCV RNA

Yuki Moritou, Fusao Ikeda, Yasuto Takeuchi, Hiroyuki Seki, Shintaro Nanba, Yoshiaki Iwasaki, Kazuhide Yamamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of

Original languageEnglish
Pages (from-to)544-548
Number of pages5
JournalJournal of Clinical Microbiology
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Hepacivirus
RNA
Serum
Serogroup
Viral Load
Nucleotides

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Necessity for reassessment of patients with serogroup 2 hepatitis C virus (HCV) and undetectable serum HCV RNA. / Moritou, Yuki; Ikeda, Fusao; Takeuchi, Yasuto; Seki, Hiroyuki; Nanba, Shintaro; Iwasaki, Yoshiaki; Yamamoto, Kazuhide.

In: Journal of Clinical Microbiology, Vol. 52, No. 2, 02.2014, p. 544-548.

Research output: Contribution to journalArticle

Moritou, Yuki ; Ikeda, Fusao ; Takeuchi, Yasuto ; Seki, Hiroyuki ; Nanba, Shintaro ; Iwasaki, Yoshiaki ; Yamamoto, Kazuhide. / Necessity for reassessment of patients with serogroup 2 hepatitis C virus (HCV) and undetectable serum HCV RNA. In: Journal of Clinical Microbiology. 2014 ; Vol. 52, No. 2. pp. 544-548.
@article{2087ea199ac54d53af6b3e03f4f54fcc,
title = "Necessity for reassessment of patients with serogroup 2 hepatitis C virus (HCV) and undetectable serum HCV RNA",
abstract = "We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of",
author = "Yuki Moritou and Fusao Ikeda and Yasuto Takeuchi and Hiroyuki Seki and Shintaro Nanba and Yoshiaki Iwasaki and Kazuhide Yamamoto",
year = "2014",
month = "2",
doi = "10.1128/JCM.02792-13",
language = "English",
volume = "52",
pages = "544--548",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Necessity for reassessment of patients with serogroup 2 hepatitis C virus (HCV) and undetectable serum HCV RNA

AU - Moritou, Yuki

AU - Ikeda, Fusao

AU - Takeuchi, Yasuto

AU - Seki, Hiroyuki

AU - Nanba, Shintaro

AU - Iwasaki, Yoshiaki

AU - Yamamoto, Kazuhide

PY - 2014/2

Y1 - 2014/2

N2 - We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of

AB - We encountered a patient positive for anti-hepatitis C virus (HCV) whose serum HCV RNA was undetectable with the Roche AmpliPrep/Cobas TaqMan HCV assay (CAP/CTM) version 1 but showed a high viral load with the Abbott RealTime HCV assay (ART). Discrepancies in the detectability of serum HCV RNA were investigated among 891 consecutive patients who were positive for anti-HCV. Specific nucleotide variations causing the undetectability of HCV RNA were determined and confirmed by synthesizing RNA coding those variations. Serum samples with the discrepancies were also reassessed by CAP/CTM version 2. Among the 891 anti-HCV-positive patients, 4 patients had serum HCV RNA levels that were undetectable by CAP/CTM version 1 despite having levels of

UR - http://www.scopus.com/inward/record.url?scp=84893150130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893150130&partnerID=8YFLogxK

U2 - 10.1128/JCM.02792-13

DO - 10.1128/JCM.02792-13

M3 - Article

C2 - 24478486

AN - SCOPUS:84893150130

VL - 52

SP - 544

EP - 548

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 2

ER -