Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation

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9 Citations (Scopus)

Abstract

Background: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. Materials and Methods: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. Results: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin-And proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. Conclusion: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.

Original languageEnglish
Pages (from-to)2113-2122
Number of pages10
JournalAnticancer Research
Volume34
Issue number5
Publication statusPublished - May 1 2014

Fingerprint

Mouth Neoplasms
Cell Proliferation
Neoplasms
Ribosomal RNA
neamine
angiogenin
Proliferating Cell Nuclear Antigen
Heterografts
Nude Mice
Endothelial Cells
Growth

Keywords

  • Angiogenesis
  • Angiogenin
  • Cell proliferation
  • Neamine
  • Oral cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation",
abstract = "Background: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. Materials and Methods: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. Results: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin-And proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. Conclusion: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.",
keywords = "Angiogenesis, Angiogenin, Cell proliferation, Neamine, Oral cancer",
author = "Koji Kishimoto and Shoko Yoshida and Soichiro Ibaragi and Norie Yoshioka and Hu, {Guo Fu} and Akira Sasaki",
year = "2014",
month = "5",
day = "1",
language = "English",
volume = "34",
pages = "2113--2122",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

TY - JOUR

T1 - Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation

AU - Kishimoto, Koji

AU - Yoshida, Shoko

AU - Ibaragi, Soichiro

AU - Yoshioka, Norie

AU - Hu, Guo Fu

AU - Sasaki, Akira

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Background: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. Materials and Methods: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. Results: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin-And proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. Conclusion: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.

AB - Background: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. Materials and Methods: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. Results: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin-And proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. Conclusion: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.

KW - Angiogenesis

KW - Angiogenin

KW - Cell proliferation

KW - Neamine

KW - Oral cancer

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