Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation

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Abstract

Background: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. Materials and Methods: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. Results: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin-And proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. Conclusion: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.

Original languageEnglish
Pages (from-to)2113-2122
Number of pages10
JournalAnticancer research
Volume34
Issue number5
Publication statusPublished - May 1 2014

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Keywords

  • Angiogenesis
  • Angiogenin
  • Cell proliferation
  • Neamine
  • Oral cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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