TY - JOUR
T1 - NBQX, a selective antagonist of the AMPA receptor, affects neither field potentials nor long-term potentiation in vivo
AU - Sato, Keiko
AU - Morimoto, Kiyoshi
AU - Yamada, Norihito
AU - Kuroda, Shigetoshi
AU - Hayabara, Toshiyuki
PY - 1995/6/19
Y1 - 1995/6/19
N2 - NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline), a selective antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, at an anticonvulsant dose of 40 mg/kg (i.p.), was shown in vivo to have no effects on either the field potentials in the piriform cortex or those in the dentate gyrus of the hippocampus. The same dose of NBQX also exerted no significant effects on long-term potentiation in the hippocampus. These results suggest that the mechanism underlying the anticonvulsant action of NBQX in vivo does not involve a suppressive action on physiological synaptic transmission. The possible clinical usefulness of AMPA receptor antagonists as antiepiletic drugs is suggested.
AB - NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline), a selective antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, at an anticonvulsant dose of 40 mg/kg (i.p.), was shown in vivo to have no effects on either the field potentials in the piriform cortex or those in the dentate gyrus of the hippocampus. The same dose of NBQX also exerted no significant effects on long-term potentiation in the hippocampus. These results suggest that the mechanism underlying the anticonvulsant action of NBQX in vivo does not involve a suppressive action on physiological synaptic transmission. The possible clinical usefulness of AMPA receptor antagonists as antiepiletic drugs is suggested.
KW - Field potential
KW - In vivo
KW - Long-term potentiation
KW - NBQX
KW - Selective AMPA receptor antagonist
UR - http://www.scopus.com/inward/record.url?scp=0028997310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028997310&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(95)00266-S
DO - 10.1016/0006-8993(95)00266-S
M3 - Article
C2 - 7552367
AN - SCOPUS:0028997310
VL - 683
SP - 279
EP - 282
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 2
ER -