NBQX, a selective antagonist of the AMPA receptor, affects neither field potentials nor long-term potentiation in vivo

Keiko Sato, Kiyoshi Morimoto, Norihito Yamada, Shigetoshi Kuroda, Toshiyuki Hayabara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline), a selective antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, at an anticonvulsant dose of 40 mg/kg (i.p.), was shown in vivo to have no effects on either the field potentials in the piriform cortex or those in the dentate gyrus of the hippocampus. The same dose of NBQX also exerted no significant effects on long-term potentiation in the hippocampus. These results suggest that the mechanism underlying the anticonvulsant action of NBQX in vivo does not involve a suppressive action on physiological synaptic transmission. The possible clinical usefulness of AMPA receptor antagonists as antiepiletic drugs is suggested.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalBrain Research
Volume683
Issue number2
DOIs
Publication statusPublished - Jun 19 1995

Keywords

  • Field potential
  • In vivo
  • Long-term potentiation
  • NBQX
  • Selective AMPA receptor antagonist

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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