Navigation-assisted pelvic resections and reconstructions for periacetabular chondrosarcomas

Tomohiro Fujiwara, Yoichi Kaneuchi, Jonathan Stevenson, Michael Parry, Vineet Kurisunkal, Rhys Clark, Yusuke Tsuda, Minna Laitinen, Robert Grimer, Lee Jeys

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: Survival in patients with chondrosarcomas has not improved over 40 years. Although emerging evidence has documented the efficacy of navigation-assisted surgery, the prognostic significance in chondrosarcomas remains unknown. We aimed to assess the clinical benefit of navigation-assisted surgery for pelvic chondrosarcomas involving the peri-acetabulum. Methods: We studied 50 patients who underwent limb-sparing surgery for periacetabular chondrosarcomas performed with navigation (n = 13) without it (n = 37) at a referral musculoskeletal oncology centre between 2000 and 2015. Results: The intralesional resection rates in the navigated and non-navigated groups were 8% (n = 1) and 19% (n = 7), respectively; all bone resection margins were clear in the navigated group. The 5-year cumulative incidence of local recurrence was 23% and 56% in the navigated and non-navigated groups, respectively (p = 0.035). There were no intra-operative complications related to use of navigation. There was a trend toward better functional outcomes in the navigated group (mean MSTS score, 67%) than the non-navigated group (mean MSTS score, 60%; p = 0.412). At a mean follow-up of 63 months, the 5-year disease-specific survival was 76% and 53% in the navigated and non-navigated group, respectively (p = 0.085), whilst the 5-year progression-free survival was 62% and 28% in the navigated and non-navigated group, respectively (p = 0.032). Conclusion: This study confirmed improved local control and progression-free survival with the use of computer navigation in patients with limb-salvage surgery for periacetabular chondrosarcomas, although the advancement in other treatment modalities is required for improvement of disease-specific survival.

Original languageEnglish
Pages (from-to)416-423
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume47
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Chondrosarcoma
  • Navigation
  • Pelvis
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

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