Natural taxanes: Developments since 1828

Yu Fang Wang, Qing Wen Shi, Mei Dong, Hiromasa Kiyota, Yu Cheng Gu, Bin Cong

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Paclitaxel is found to be a natural taxane with the most potential. After two decades of effort, at least six groups have achieved the total synthesis of paclitaxel. A diverse strategy and excellent approaches for the synthesis of the taxane framework and for paclitaxel itself were evolved. The construction of the taxane framework with the oxetane ring and the homochiral ester side-chain at C-13 become challenges for synthetic chemists. The in vivo productions of paclitaxel in plant tissue and cell culture have not provided economically feasible solutions to the paclitaxel supply problem. Biotransformation of taxanes, and cell or tissue culture provide breakthroughs continuously for improvement of the paclitaxel production by biological methods. Bioactivity studies of natural taxanes were carried out mostly by Kobayashi group and three comprehensive reviews have been published on these works.

Original languageEnglish
Pages (from-to)7652-7709
Number of pages58
JournalChemical Reviews
Volume111
Issue number12
DOIs
Publication statusPublished - Dec 14 2011
Externally publishedYes

Fingerprint

Taxoids
Paclitaxel
Tissue culture
Cell culture
Bioactivity
Esters
taxane

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Wang, Y. F., Shi, Q. W., Dong, M., Kiyota, H., Gu, Y. C., & Cong, B. (2011). Natural taxanes: Developments since 1828. Chemical Reviews, 111(12), 7652-7709. https://doi.org/10.1021/cr100147u

Natural taxanes : Developments since 1828. / Wang, Yu Fang; Shi, Qing Wen; Dong, Mei; Kiyota, Hiromasa; Gu, Yu Cheng; Cong, Bin.

In: Chemical Reviews, Vol. 111, No. 12, 14.12.2011, p. 7652-7709.

Research output: Contribution to journalArticle

Wang, YF, Shi, QW, Dong, M, Kiyota, H, Gu, YC & Cong, B 2011, 'Natural taxanes: Developments since 1828', Chemical Reviews, vol. 111, no. 12, pp. 7652-7709. https://doi.org/10.1021/cr100147u
Wang YF, Shi QW, Dong M, Kiyota H, Gu YC, Cong B. Natural taxanes: Developments since 1828. Chemical Reviews. 2011 Dec 14;111(12):7652-7709. https://doi.org/10.1021/cr100147u
Wang, Yu Fang ; Shi, Qing Wen ; Dong, Mei ; Kiyota, Hiromasa ; Gu, Yu Cheng ; Cong, Bin. / Natural taxanes : Developments since 1828. In: Chemical Reviews. 2011 ; Vol. 111, No. 12. pp. 7652-7709.
@article{f08208271aa24cc99df221caf315a3a1,
title = "Natural taxanes: Developments since 1828",
abstract = "Paclitaxel is found to be a natural taxane with the most potential. After two decades of effort, at least six groups have achieved the total synthesis of paclitaxel. A diverse strategy and excellent approaches for the synthesis of the taxane framework and for paclitaxel itself were evolved. The construction of the taxane framework with the oxetane ring and the homochiral ester side-chain at C-13 become challenges for synthetic chemists. The in vivo productions of paclitaxel in plant tissue and cell culture have not provided economically feasible solutions to the paclitaxel supply problem. Biotransformation of taxanes, and cell or tissue culture provide breakthroughs continuously for improvement of the paclitaxel production by biological methods. Bioactivity studies of natural taxanes were carried out mostly by Kobayashi group and three comprehensive reviews have been published on these works.",
author = "Wang, {Yu Fang} and Shi, {Qing Wen} and Mei Dong and Hiromasa Kiyota and Gu, {Yu Cheng} and Bin Cong",
year = "2011",
month = "12",
day = "14",
doi = "10.1021/cr100147u",
language = "English",
volume = "111",
pages = "7652--7709",
journal = "Chemical Reviews",
issn = "0009-2665",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Natural taxanes

T2 - Developments since 1828

AU - Wang, Yu Fang

AU - Shi, Qing Wen

AU - Dong, Mei

AU - Kiyota, Hiromasa

AU - Gu, Yu Cheng

AU - Cong, Bin

PY - 2011/12/14

Y1 - 2011/12/14

N2 - Paclitaxel is found to be a natural taxane with the most potential. After two decades of effort, at least six groups have achieved the total synthesis of paclitaxel. A diverse strategy and excellent approaches for the synthesis of the taxane framework and for paclitaxel itself were evolved. The construction of the taxane framework with the oxetane ring and the homochiral ester side-chain at C-13 become challenges for synthetic chemists. The in vivo productions of paclitaxel in plant tissue and cell culture have not provided economically feasible solutions to the paclitaxel supply problem. Biotransformation of taxanes, and cell or tissue culture provide breakthroughs continuously for improvement of the paclitaxel production by biological methods. Bioactivity studies of natural taxanes were carried out mostly by Kobayashi group and three comprehensive reviews have been published on these works.

AB - Paclitaxel is found to be a natural taxane with the most potential. After two decades of effort, at least six groups have achieved the total synthesis of paclitaxel. A diverse strategy and excellent approaches for the synthesis of the taxane framework and for paclitaxel itself were evolved. The construction of the taxane framework with the oxetane ring and the homochiral ester side-chain at C-13 become challenges for synthetic chemists. The in vivo productions of paclitaxel in plant tissue and cell culture have not provided economically feasible solutions to the paclitaxel supply problem. Biotransformation of taxanes, and cell or tissue culture provide breakthroughs continuously for improvement of the paclitaxel production by biological methods. Bioactivity studies of natural taxanes were carried out mostly by Kobayashi group and three comprehensive reviews have been published on these works.

UR - http://www.scopus.com/inward/record.url?scp=80155147586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80155147586&partnerID=8YFLogxK

U2 - 10.1021/cr100147u

DO - 10.1021/cr100147u

M3 - Article

C2 - 21970550

AN - SCOPUS:80155147586

VL - 111

SP - 7652

EP - 7709

JO - Chemical Reviews

JF - Chemical Reviews

SN - 0009-2665

IS - 12

ER -