Natural killer (NK) cell activity and NK cell subsets in workers with a tendency of burnout

Hiroyuki Nakamura, Hirofumi Nagase, Masami Yoshida, Keiki Ogino

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The involvement of cellular immunity in the burnout syndrome remains to be elucidated. We assessed three components of burnout of the Maslach Burnout Inventory: emotional exhaustion; depersonalization (DP); and personal accomplishment, as well as natural killer cell activity (NKCA) and NK cell subsets in 42 male workers. Workers with a higher DP score showed a lower NKCA and a lower proportionality of CD57+CD16+ to total lymphocytes. There were no differences in any of the health behaviors (e.g., smoking, alcohol, or obesity) between workers showing higher burnout and those showing lower burnout. A stepwise multiple regressions analysis demonstrated that NKCA was closely correlated with DP, independent of other variables, including a stress index. These results suggest that the relationship between reduced cellular immunity and DP is not due to traditional work stress or health behavioral problems. Further studies on DP as a psychosomatic disorder as well as an occupational health problem should be performed in the future.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalJournal of Psychosomatic Research
Volume46
Issue number6
DOIs
Publication statusPublished - Jun 1999
Externally publishedYes

Fingerprint

Depersonalization
Natural Killer Cells
Cellular Immunity
Psychophysiologic Disorders
Health Behavior
Occupational Health
Obesity
Smoking
Regression Analysis
Alcohols
Lymphocytes
Equipment and Supplies
Health

Keywords

  • Burnout
  • Cellular immunity
  • Natural killer cell (NK) cell subsets
  • NK cell activity
  • Stress
  • Work

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Natural killer (NK) cell activity and NK cell subsets in workers with a tendency of burnout. / Nakamura, Hiroyuki; Nagase, Hirofumi; Yoshida, Masami; Ogino, Keiki.

In: Journal of Psychosomatic Research, Vol. 46, No. 6, 06.1999, p. 569-578.

Research output: Contribution to journalArticle

Nakamura, Hiroyuki ; Nagase, Hirofumi ; Yoshida, Masami ; Ogino, Keiki. / Natural killer (NK) cell activity and NK cell subsets in workers with a tendency of burnout. In: Journal of Psychosomatic Research. 1999 ; Vol. 46, No. 6. pp. 569-578.
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