Natural killer cell activity reduced by microwave exposure during pregnancy is mediated by opioid systems

Hiroyuki Nakamura, Toshio Seto, Kotaro Hatta, Ichiyo Matsuzaki, Hirofumi Nagase, Masami Yoshida, Keiki Ogino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have previously demonstrated immunosuppression including reduced splenic natural killer cell activity (NKCA) in pregnant rats exposed to microwaves produced mainly by their thermal action. To examine the involvement of opioid systems in reduced NKCA in pregnant rats exposed to microwaves at a relatively low level (2 mW/cm2 incident power density at 2450 MHz for 90 min), we assayed β-endorphin (βEP) in blood, pituitary lobes, and placenta as well as splenic NKCA in virgin and/or pregnant rats. Although microwaves elevated colonic temperatures by 0.8°C for virgin and 0.9°C for pregnant rats, and βEP in blood and anterior pituitary lobes (ALP) significantly, it did not change blood corticosterone as an index of hypothalamic-pituitary adrenal axis. There were significant interactions between pregnancy and microwave exposure on splenic NKCA, βEP in both blood and AP, and blood progesterone. Intraperitoneal administration of opioid receptor antagonist naloxone prior to microwave exposure increased NKCA, blood, and placental βEP in pregnant rats. Alterations in splenic NKCA, βEP and progesterone in pregnant rats exposed to microwaves may be due to both thermal and nonthermal actions. These results suggest that NKCA reduced by microwaves during pregnancy is mediated by the pituitary opioid system.

Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalEnvironmental Research
Volume79
Issue number2
DOIs
Publication statusPublished - Nov 1998
Externally publishedYes

Fingerprint

Microwaves
pregnancy
Endorphins
Natural Killer Cells
Opioid Analgesics
Rats
Blood
blood
Pregnancy
Progesterone
Hot Temperature
Anterior Pituitary Gland
Narcotic Antagonists
Naloxone
Corticosterone
microwave
exposure
Immunosuppression
Placenta
Temperature

Keywords

  • β-endorphin
  • Immunosuppression
  • Naloxone
  • Pitutary
  • Placenta

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Nakamura, H., Seto, T., Hatta, K., Matsuzaki, I., Nagase, H., Yoshida, M., & Ogino, K. (1998). Natural killer cell activity reduced by microwave exposure during pregnancy is mediated by opioid systems. Environmental Research, 79(2), 106-113. https://doi.org/10.1006/enrs.1998.3866

Natural killer cell activity reduced by microwave exposure during pregnancy is mediated by opioid systems. / Nakamura, Hiroyuki; Seto, Toshio; Hatta, Kotaro; Matsuzaki, Ichiyo; Nagase, Hirofumi; Yoshida, Masami; Ogino, Keiki.

In: Environmental Research, Vol. 79, No. 2, 11.1998, p. 106-113.

Research output: Contribution to journalArticle

Nakamura, H, Seto, T, Hatta, K, Matsuzaki, I, Nagase, H, Yoshida, M & Ogino, K 1998, 'Natural killer cell activity reduced by microwave exposure during pregnancy is mediated by opioid systems', Environmental Research, vol. 79, no. 2, pp. 106-113. https://doi.org/10.1006/enrs.1998.3866
Nakamura, Hiroyuki ; Seto, Toshio ; Hatta, Kotaro ; Matsuzaki, Ichiyo ; Nagase, Hirofumi ; Yoshida, Masami ; Ogino, Keiki. / Natural killer cell activity reduced by microwave exposure during pregnancy is mediated by opioid systems. In: Environmental Research. 1998 ; Vol. 79, No. 2. pp. 106-113.
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