Abstract
Sense of Coherence (SOC), a candidate for a mediating stress factor, is studied in the framework of Antonovsky's salutogenesis paradigm, which emphasizes the origin of health. Emotional stress is associated with a decrease in cellular immune function including natural killer cell activity (NKCA). The purpose of this study was to clarify the involvement of SOC and smoking behavior in cellular immunity including NKCA. The author performed a psychological questionnaire and examined NKCA and NK cell subsets in 125 men (45.1 ± 7.88 yr, mean ± SD) engaged in office work. The psychosocial factors included SOC and health locus of control (HLC) as well as perceived life stress and life style. SOC and smoking status was recognized to affect NKCA as well as CD57+CD16+. A higher SOC and never smoking significantly contributed to a higher level of NKCA. In subjects with a higher SOC, NKCA in never and ex-smokers were significantly higher than those in present smokers, whereas in subjects with a lower SOC, NKCA only in never smokers was significantly higher than that in present smokers. There were no significant differences in the stress index, alcohol obesity, or HLC among smoking status. SOC showed a moderately negative relationship with life stress. Multiple regression analysis demonstrated that SOC and smoking were significantly correlated to NKCA and CD57+CD16+, independently of other psychosocial variables, suggesting salutogenic contributions of SOC. SOC may be an important psychological modifier in determining the relationship between cellular immunity and smoking cessation. The reduced NKCA with lower SOC in present smokers, whose association seems to be produced not through daily life stress, must be dealt with as an occupational mental health problem.
| Original language | English |
|---|---|
| Pages (from-to) | 191-198 |
| Number of pages | 8 |
| Journal | Journal of Occupational Health |
| Volume | 43 |
| Issue number | 4 |
| Publication status | Published - 2001 |
| Externally published | Yes |
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Keywords
- Cellular immunity
- Natural killer cell activity
- Sense of coherence
- Smoking
- Stress
- Work
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Toxicology
Cite this
Natural killer cell activity and its related psychological factor, sense of coherence in male smokers. / Nakamura, Hiroyuki; Ogawa, Yukie; Nagase, Hirofumi; Nagajima, Madoka; Kodama, Norio; Ogino, Keiki; Ooshita, Yoshiko.
In: Journal of Occupational Health, Vol. 43, No. 4, 2001, p. 191-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural killer cell activity and its related psychological factor, sense of coherence in male smokers
AU - Nakamura, Hiroyuki
AU - Ogawa, Yukie
AU - Nagase, Hirofumi
AU - Nagajima, Madoka
AU - Kodama, Norio
AU - Ogino, Keiki
AU - Ooshita, Yoshiko
PY - 2001
Y1 - 2001
N2 - Sense of Coherence (SOC), a candidate for a mediating stress factor, is studied in the framework of Antonovsky's salutogenesis paradigm, which emphasizes the origin of health. Emotional stress is associated with a decrease in cellular immune function including natural killer cell activity (NKCA). The purpose of this study was to clarify the involvement of SOC and smoking behavior in cellular immunity including NKCA. The author performed a psychological questionnaire and examined NKCA and NK cell subsets in 125 men (45.1 ± 7.88 yr, mean ± SD) engaged in office work. The psychosocial factors included SOC and health locus of control (HLC) as well as perceived life stress and life style. SOC and smoking status was recognized to affect NKCA as well as CD57+CD16+. A higher SOC and never smoking significantly contributed to a higher level of NKCA. In subjects with a higher SOC, NKCA in never and ex-smokers were significantly higher than those in present smokers, whereas in subjects with a lower SOC, NKCA only in never smokers was significantly higher than that in present smokers. There were no significant differences in the stress index, alcohol obesity, or HLC among smoking status. SOC showed a moderately negative relationship with life stress. Multiple regression analysis demonstrated that SOC and smoking were significantly correlated to NKCA and CD57+CD16+, independently of other psychosocial variables, suggesting salutogenic contributions of SOC. SOC may be an important psychological modifier in determining the relationship between cellular immunity and smoking cessation. The reduced NKCA with lower SOC in present smokers, whose association seems to be produced not through daily life stress, must be dealt with as an occupational mental health problem.
AB - Sense of Coherence (SOC), a candidate for a mediating stress factor, is studied in the framework of Antonovsky's salutogenesis paradigm, which emphasizes the origin of health. Emotional stress is associated with a decrease in cellular immune function including natural killer cell activity (NKCA). The purpose of this study was to clarify the involvement of SOC and smoking behavior in cellular immunity including NKCA. The author performed a psychological questionnaire and examined NKCA and NK cell subsets in 125 men (45.1 ± 7.88 yr, mean ± SD) engaged in office work. The psychosocial factors included SOC and health locus of control (HLC) as well as perceived life stress and life style. SOC and smoking status was recognized to affect NKCA as well as CD57+CD16+. A higher SOC and never smoking significantly contributed to a higher level of NKCA. In subjects with a higher SOC, NKCA in never and ex-smokers were significantly higher than those in present smokers, whereas in subjects with a lower SOC, NKCA only in never smokers was significantly higher than that in present smokers. There were no significant differences in the stress index, alcohol obesity, or HLC among smoking status. SOC showed a moderately negative relationship with life stress. Multiple regression analysis demonstrated that SOC and smoking were significantly correlated to NKCA and CD57+CD16+, independently of other psychosocial variables, suggesting salutogenic contributions of SOC. SOC may be an important psychological modifier in determining the relationship between cellular immunity and smoking cessation. The reduced NKCA with lower SOC in present smokers, whose association seems to be produced not through daily life stress, must be dealt with as an occupational mental health problem.
KW - Cellular immunity
KW - Natural killer cell activity
KW - Sense of coherence
KW - Smoking
KW - Stress
KW - Work
UR - http://www.scopus.com/inward/record.url?scp=0034874531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034874531&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034874531
VL - 43
SP - 191
EP - 198
JO - Journal of Occupational Health
JF - Journal of Occupational Health
SN - 1341-9145
IS - 4
ER -