TY - JOUR
T1 - Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer
AU - Terazawa, Akio
AU - Tanaka, Noriaki
AU - Senou, Noritomo
AU - Inoue, Fumiyuki
AU - Matsuura, Hiroo
AU - Gouchi, Akira
AU - Fuchimoto, Sadayoshi
AU - Mimura, Hisashi
AU - Orita, Kunzo
PY - 1987/7
Y1 - 1987/7
N2 - This investigation was intended to determine whether the natural killer (NK) activity of peripheral blood lymphocytes (PBL) correlated with the histopathological factor, which is thought to be a result of a balance between tumor aggression and host resistance. The NK activity of PBL from 60 patients with lung cancer was measured by the lysis of51Cr-labelled K562 target cells. The activity was significantly decreased with advancing stages of the disease, and inversely correlated with increased immunosuppressive substance levels of the serum. Histopathological factors, such as low grade pleural invasion of the tumor and abundant lymphoid cell infiltration around the tumor, were significantly associated with the high NK activity of PBL. These results show that a decrease in NK activity may play a role in identifying those individuals with a greater risk of cancer development.
AB - This investigation was intended to determine whether the natural killer (NK) activity of peripheral blood lymphocytes (PBL) correlated with the histopathological factor, which is thought to be a result of a balance between tumor aggression and host resistance. The NK activity of PBL from 60 patients with lung cancer was measured by the lysis of51Cr-labelled K562 target cells. The activity was significantly decreased with advancing stages of the disease, and inversely correlated with increased immunosuppressive substance levels of the serum. Histopathological factors, such as low grade pleural invasion of the tumor and abundant lymphoid cell infiltration around the tumor, were significantly associated with the high NK activity of PBL. These results show that a decrease in NK activity may play a role in identifying those individuals with a greater risk of cancer development.
KW - blood vessel invasion
KW - local lymphoid cell infiltration
KW - lung cancer
KW - natural killer activity
KW - pleural invasion
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U2 - 10.1007/BF02470694
DO - 10.1007/BF02470694
M3 - Article
C2 - 3682431
AN - SCOPUS:0023367990
SN - 0941-1291
VL - 17
SP - 236
EP - 242
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
IS - 4
ER -
