Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer

Akio Terazawa, Noriaki Tanaka, Noritomo Senou, Fumiyuki Inoue, Hiroo Matsuura, Akira Gouchi, Sadayoshi Fuchimoto, Hisashi Mimura, Kunzo Orita

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This investigation was intended to determine whether the natural killer (NK) activity of peripheral blood lymphocytes (PBL) correlated with the histopathological factor, which is thought to be a result of a balance between tumor aggression and host resistance. The NK activity of PBL from 60 patients with lung cancer was measured by the lysis of51Cr-labelled K562 target cells. The activity was significantly decreased with advancing stages of the disease, and inversely correlated with increased immunosuppressive substance levels of the serum. Histopathological factors, such as low grade pleural invasion of the tumor and abundant lymphoid cell infiltration around the tumor, were significantly associated with the high NK activity of PBL. These results show that a decrease in NK activity may play a role in identifying those individuals with a greater risk of cancer development.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalThe Japanese Journal of Surgery
Volume17
Issue number4
DOIs
Publication statusPublished - Jul 1987

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Lung Neoplasms
Lymphocytes
Neoplasms
K562 Cells
Immunosuppressive Agents
Aggression
Serum

Keywords

  • blood vessel invasion
  • local lymphoid cell infiltration
  • lung cancer
  • natural killer activity
  • pleural invasion

ASJC Scopus subject areas

  • Surgery

Cite this

Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer. / Terazawa, Akio; Tanaka, Noriaki; Senou, Noritomo; Inoue, Fumiyuki; Matsuura, Hiroo; Gouchi, Akira; Fuchimoto, Sadayoshi; Mimura, Hisashi; Orita, Kunzo.

In: The Japanese Journal of Surgery, Vol. 17, No. 4, 07.1987, p. 236-242.

Research output: Contribution to journalArticle

Terazawa, A, Tanaka, N, Senou, N, Inoue, F, Matsuura, H, Gouchi, A, Fuchimoto, S, Mimura, H & Orita, K 1987, 'Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer', The Japanese Journal of Surgery, vol. 17, no. 4, pp. 236-242. https://doi.org/10.1007/BF02470694
Terazawa, Akio ; Tanaka, Noriaki ; Senou, Noritomo ; Inoue, Fumiyuki ; Matsuura, Hiroo ; Gouchi, Akira ; Fuchimoto, Sadayoshi ; Mimura, Hisashi ; Orita, Kunzo. / Natural killer activity of peripheral blood lymphocytes and its relation to histopathological factors of lung cancer. In: The Japanese Journal of Surgery. 1987 ; Vol. 17, No. 4. pp. 236-242.
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