Natural history of dilated cardiomyopathy in children

Teiji Akagi, Lee N. Benson, Nancy E. Lightfoot, Kerrison Chin, Greg Wilson, Robert M. Freedom

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

To assess the natural history and potential risk factors in childhood dilated cardlomyopathy, we investigated 25 patients (ages 9.6 ± 4.4 years) who presented after they were 2 years old. All patients had symptoms of congestive heart failure and reduced contractility with a dilated left ventricle at presentation. Two factors at presentation were significantly different between patients who died less than 1 year after the presentation (n = 14) and those who survived for more than 1 year (n = 9); cardiothoracic ratio (65.1% ± 6.8% vs 57.1% ± 6.1%, p <0.01) and left ventricular ejection fraction (31.3% ± 7.0% vs 40.0% ± 6.2%, p <0.05). Irrespective of intensive medical therapy, dilated cardiomyopathy in children had a poor prognosis; the actuarial survival rate was 41% at 1 year and 20% at 3 years. Other forms of therapy should be considered in the early stages of dilated cardiomyopathy in this high-risk group.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalAmerican Heart Journal
Volume121
Issue number5
DOIs
Publication statusPublished - 1991
Externally publishedYes

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Dilated Cardiomyopathy
Natural History
Stroke Volume
Heart Ventricles
Survival Rate
Heart Failure
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Akagi, T., Benson, L. N., Lightfoot, N. E., Chin, K., Wilson, G., & Freedom, R. M. (1991). Natural history of dilated cardiomyopathy in children. American Heart Journal, 121(5), 1502-1506. https://doi.org/10.1016/0002-8703(91)90158-E

Natural history of dilated cardiomyopathy in children. / Akagi, Teiji; Benson, Lee N.; Lightfoot, Nancy E.; Chin, Kerrison; Wilson, Greg; Freedom, Robert M.

In: American Heart Journal, Vol. 121, No. 5, 1991, p. 1502-1506.

Research output: Contribution to journalArticle

Akagi, T, Benson, LN, Lightfoot, NE, Chin, K, Wilson, G & Freedom, RM 1991, 'Natural history of dilated cardiomyopathy in children', American Heart Journal, vol. 121, no. 5, pp. 1502-1506. https://doi.org/10.1016/0002-8703(91)90158-E
Akagi T, Benson LN, Lightfoot NE, Chin K, Wilson G, Freedom RM. Natural history of dilated cardiomyopathy in children. American Heart Journal. 1991;121(5):1502-1506. https://doi.org/10.1016/0002-8703(91)90158-E
Akagi, Teiji ; Benson, Lee N. ; Lightfoot, Nancy E. ; Chin, Kerrison ; Wilson, Greg ; Freedom, Robert M. / Natural history of dilated cardiomyopathy in children. In: American Heart Journal. 1991 ; Vol. 121, No. 5. pp. 1502-1506.
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