Natural history of dilated cardiomyopathy in children

Teiji Akagi, Lee N. Benson, Nancy E. Lightfoot, Kerrison Chin, Greg Wilson, Robert M. Freedom

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Abstract

To assess the natural history and potential risk factors in childhood dilated cardlomyopathy, we investigated 25 patients (ages 9.6 ± 4.4 years) who presented after they were 2 years old. All patients had symptoms of congestive heart failure and reduced contractility with a dilated left ventricle at presentation. Two factors at presentation were significantly different between patients who died less than 1 year after the presentation (n = 14) and those who survived for more than 1 year (n = 9); cardiothoracic ratio (65.1% ± 6.8% vs 57.1% ± 6.1%, p < 0.01) and left ventricular ejection fraction (31.3% ± 7.0% vs 40.0% ± 6.2%, p < 0.05). Irrespective of intensive medical therapy, dilated cardiomyopathy in children had a poor prognosis; the actuarial survival rate was 41% at 1 year and 20% at 3 years. Other forms of therapy should be considered in the early stages of dilated cardiomyopathy in this high-risk group.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalAmerican Heart Journal
Volume121
Issue number5
DOIs
Publication statusPublished - May 1991
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Akagi, T., Benson, L. N., Lightfoot, N. E., Chin, K., Wilson, G., & Freedom, R. M. (1991). Natural history of dilated cardiomyopathy in children. American Heart Journal, 121(5), 1502-1506. https://doi.org/10.1016/0002-8703(91)90158-E