Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009

Keizo Yamaguchi, Yoshikazu Ishii, Morihiro Iwata, Naoki Watanabe, Masaaki Shinagawa, Minoru Yasujima, Akira Suwabe, Makiko Kuroda, Mitsuo Kaku, Miho Kitagawa, Keiji Kanemitsu, Yuji Imafuku, Masami Murakami, Sachie Yomoda, Nobuyuki Taniguchi, Toshiyuki Yamada, Fumio Nomura, Harushige Kanno, Shigefumi Maesaki, Giichi HashikitaShigemi Kondo, Shigeki Misawa, Hajime Horiuchi, Yoko Tazawa, Hideki Nakashima, Hiromu Takemura, Masahiko Okada, Yoshinori Horikawa, Masato Maekawa, Osanori Nagura, Tetsuya Yagi, Hisashi Baba, Shiomi Ishigo, Naohisa Fujita, Toshiaki Komori, Satoshi Ichiyama, Kiyoharu Yamanaka, Yoko Murata, Shuji Matsuo, Hisashi Kohno, Seiji Kawano, Shohiro Kinoshita, Tomohiko Taminato, Kiyoshi Negayama, Mitsuharu Murase, Hitoshi Miyamoto, Nobuchika Kusano, Motoko Nose, Michiya Yokozaki, Hideyuki Itaha, Akira Matsunaga, Hisae Yoshimura, Shigeru Kohno, Katsunori Yanagihara, Junichi Matsuda, Tetsunori Saikawa, Kazufumi Hiramatsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The antibacterial activity of meropenem (MEPM) and other parenteral antibiotics against clinical isolates of 2655 strains including 810 strains of Gram-positive bacteria, 1635 strains of Gram-negative bacteria, and 210 strains of anaerobic bacteria obtained from 30 medical institutions during 2009 was examined. The results were as follows; 1. MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA). 2. MEPM maintained potent and stable antibacterial activity against Pesudomonas aeruginosa. The proportion of MEPM-resistant strains to ciprofloxacin-resistant strains or imipenem-resistant strains were 53.1% and 58.0% respectively. 3. The proportion of extended-spectrum β-lactamase (ESBL) strains was 3.1% (26 strains) in enterobacteriaceae. And the proportion of metallo-β-lactamase strains was 2.0% (6 strains) in P. aeruginosa. 4. Of all species tested, there were no species except for Bacteroides fragilis group, which MIC90 of MEPM was more than 4-fold higher than those in our previous study. Therefore, there is almost no significant decrease in susceptibility of clinical isolates to meropenem. In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem for serious infections treatment at present, 14 years passed after available for commercial use in Japan.

Original languageEnglish
Pages (from-to)53-95
Number of pages43
JournalJapanese Journal of Antibiotics
Volume64
Issue number2
Publication statusPublished - Apr 2011

Fingerprint

meropenem
Anti-Bacterial Agents
Carbapenems
Anaerobic Bacteria
Gram-Positive Bacteria
Enterobacteriaceae
Gram-Negative Bacteria
Bacteroides fragilis
Imipenem
Haemophilus influenzae
Methicillin-Resistant Staphylococcus aureus
Ciprofloxacin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Yamaguchi, K., Ishii, Y., Iwata, M., Watanabe, N., Shinagawa, M., Yasujima, M., ... Hiramatsu, K. (2011). Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009. Japanese Journal of Antibiotics, 64(2), 53-95.

Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009. / Yamaguchi, Keizo; Ishii, Yoshikazu; Iwata, Morihiro; Watanabe, Naoki; Shinagawa, Masaaki; Yasujima, Minoru; Suwabe, Akira; Kuroda, Makiko; Kaku, Mitsuo; Kitagawa, Miho; Kanemitsu, Keiji; Imafuku, Yuji; Murakami, Masami; Yomoda, Sachie; Taniguchi, Nobuyuki; Yamada, Toshiyuki; Nomura, Fumio; Kanno, Harushige; Maesaki, Shigefumi; Hashikita, Giichi; Kondo, Shigemi; Misawa, Shigeki; Horiuchi, Hajime; Tazawa, Yoko; Nakashima, Hideki; Takemura, Hiromu; Okada, Masahiko; Horikawa, Yoshinori; Maekawa, Masato; Nagura, Osanori; Yagi, Tetsuya; Baba, Hisashi; Ishigo, Shiomi; Fujita, Naohisa; Komori, Toshiaki; Ichiyama, Satoshi; Yamanaka, Kiyoharu; Murata, Yoko; Matsuo, Shuji; Kohno, Hisashi; Kawano, Seiji; Kinoshita, Shohiro; Taminato, Tomohiko; Negayama, Kiyoshi; Murase, Mitsuharu; Miyamoto, Hitoshi; Kusano, Nobuchika; Nose, Motoko; Yokozaki, Michiya; Itaha, Hideyuki; Matsunaga, Akira; Yoshimura, Hisae; Kohno, Shigeru; Yanagihara, Katsunori; Matsuda, Junichi; Saikawa, Tetsunori; Hiramatsu, Kazufumi.

In: Japanese Journal of Antibiotics, Vol. 64, No. 2, 04.2011, p. 53-95.

Research output: Contribution to journalArticle

Yamaguchi, K, Ishii, Y, Iwata, M, Watanabe, N, Shinagawa, M, Yasujima, M, Suwabe, A, Kuroda, M, Kaku, M, Kitagawa, M, Kanemitsu, K, Imafuku, Y, Murakami, M, Yomoda, S, Taniguchi, N, Yamada, T, Nomura, F, Kanno, H, Maesaki, S, Hashikita, G, Kondo, S, Misawa, S, Horiuchi, H, Tazawa, Y, Nakashima, H, Takemura, H, Okada, M, Horikawa, Y, Maekawa, M, Nagura, O, Yagi, T, Baba, H, Ishigo, S, Fujita, N, Komori, T, Ichiyama, S, Yamanaka, K, Murata, Y, Matsuo, S, Kohno, H, Kawano, S, Kinoshita, S, Taminato, T, Negayama, K, Murase, M, Miyamoto, H, Kusano, N, Nose, M, Yokozaki, M, Itaha, H, Matsunaga, A, Yoshimura, H, Kohno, S, Yanagihara, K, Matsuda, J, Saikawa, T & Hiramatsu, K 2011, 'Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009', Japanese Journal of Antibiotics, vol. 64, no. 2, pp. 53-95.
Yamaguchi, Keizo ; Ishii, Yoshikazu ; Iwata, Morihiro ; Watanabe, Naoki ; Shinagawa, Masaaki ; Yasujima, Minoru ; Suwabe, Akira ; Kuroda, Makiko ; Kaku, Mitsuo ; Kitagawa, Miho ; Kanemitsu, Keiji ; Imafuku, Yuji ; Murakami, Masami ; Yomoda, Sachie ; Taniguchi, Nobuyuki ; Yamada, Toshiyuki ; Nomura, Fumio ; Kanno, Harushige ; Maesaki, Shigefumi ; Hashikita, Giichi ; Kondo, Shigemi ; Misawa, Shigeki ; Horiuchi, Hajime ; Tazawa, Yoko ; Nakashima, Hideki ; Takemura, Hiromu ; Okada, Masahiko ; Horikawa, Yoshinori ; Maekawa, Masato ; Nagura, Osanori ; Yagi, Tetsuya ; Baba, Hisashi ; Ishigo, Shiomi ; Fujita, Naohisa ; Komori, Toshiaki ; Ichiyama, Satoshi ; Yamanaka, Kiyoharu ; Murata, Yoko ; Matsuo, Shuji ; Kohno, Hisashi ; Kawano, Seiji ; Kinoshita, Shohiro ; Taminato, Tomohiko ; Negayama, Kiyoshi ; Murase, Mitsuharu ; Miyamoto, Hitoshi ; Kusano, Nobuchika ; Nose, Motoko ; Yokozaki, Michiya ; Itaha, Hideyuki ; Matsunaga, Akira ; Yoshimura, Hisae ; Kohno, Shigeru ; Yanagihara, Katsunori ; Matsuda, Junichi ; Saikawa, Tetsunori ; Hiramatsu, Kazufumi. / Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2009. In: Japanese Journal of Antibiotics. 2011 ; Vol. 64, No. 2. pp. 53-95.
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abstract = "The antibacterial activity of meropenem (MEPM) and other parenteral antibiotics against clinical isolates of 2655 strains including 810 strains of Gram-positive bacteria, 1635 strains of Gram-negative bacteria, and 210 strains of anaerobic bacteria obtained from 30 medical institutions during 2009 was examined. The results were as follows; 1. MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA). 2. MEPM maintained potent and stable antibacterial activity against Pesudomonas aeruginosa. The proportion of MEPM-resistant strains to ciprofloxacin-resistant strains or imipenem-resistant strains were 53.1{\%} and 58.0{\%} respectively. 3. The proportion of extended-spectrum β-lactamase (ESBL) strains was 3.1{\%} (26 strains) in enterobacteriaceae. And the proportion of metallo-β-lactamase strains was 2.0{\%} (6 strains) in P. aeruginosa. 4. Of all species tested, there were no species except for Bacteroides fragilis group, which MIC90 of MEPM was more than 4-fold higher than those in our previous study. Therefore, there is almost no significant decrease in susceptibility of clinical isolates to meropenem. In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem for serious infections treatment at present, 14 years passed after available for commercial use in Japan.",
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AU - Yamaguchi, Keizo

AU - Ishii, Yoshikazu

AU - Iwata, Morihiro

AU - Watanabe, Naoki

AU - Shinagawa, Masaaki

AU - Yasujima, Minoru

AU - Suwabe, Akira

AU - Kuroda, Makiko

AU - Kaku, Mitsuo

AU - Kitagawa, Miho

AU - Kanemitsu, Keiji

AU - Imafuku, Yuji

AU - Murakami, Masami

AU - Yomoda, Sachie

AU - Taniguchi, Nobuyuki

AU - Yamada, Toshiyuki

AU - Nomura, Fumio

AU - Kanno, Harushige

AU - Maesaki, Shigefumi

AU - Hashikita, Giichi

AU - Kondo, Shigemi

AU - Misawa, Shigeki

AU - Horiuchi, Hajime

AU - Tazawa, Yoko

AU - Nakashima, Hideki

AU - Takemura, Hiromu

AU - Okada, Masahiko

AU - Horikawa, Yoshinori

AU - Maekawa, Masato

AU - Nagura, Osanori

AU - Yagi, Tetsuya

AU - Baba, Hisashi

AU - Ishigo, Shiomi

AU - Fujita, Naohisa

AU - Komori, Toshiaki

AU - Ichiyama, Satoshi

AU - Yamanaka, Kiyoharu

AU - Murata, Yoko

AU - Matsuo, Shuji

AU - Kohno, Hisashi

AU - Kawano, Seiji

AU - Kinoshita, Shohiro

AU - Taminato, Tomohiko

AU - Negayama, Kiyoshi

AU - Murase, Mitsuharu

AU - Miyamoto, Hitoshi

AU - Kusano, Nobuchika

AU - Nose, Motoko

AU - Yokozaki, Michiya

AU - Itaha, Hideyuki

AU - Matsunaga, Akira

AU - Yoshimura, Hisae

AU - Kohno, Shigeru

AU - Yanagihara, Katsunori

AU - Matsuda, Junichi

AU - Saikawa, Tetsunori

AU - Hiramatsu, Kazufumi

PY - 2011/4

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