Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2008: General view of the pathogens' antibacterial susceptibility

Yoshihito Niki, Hideaki Hanaki, Tetsuya Matsumoto, Morimasa Yagisawa, Shigeru Kohno, Nobuki Aoki, Akira Watanabe, Junko Sato, Rikizo Hattori, Naoto Koashi, Michinori Terada, Tsuneo Kozuki, Akinori Maruo, Kohei Morita, Kazuhiko Ogasawara, Yoshisaburo Takahashi, Kenji Matsuda, Kunio Nakanishi, Keisuke Sunakawa, Kenichi TakeuchiSeiichi Fujimura, Hiroaki Takeda, Hideki Ikeda, Naohito Sato, Katsunao Niitsuma, Miwako Saito, Shizuko Koshiba, Michiyo Kaneko, Makoto Miki, Susumu Nakanowatari, Hiroshi Takahashi, Mutsuko Utagawa, Hajime Nishiya, Sayoko Kawakami, Yasuko Aoki, Naohiko Chonabayashi, Hideko Sugiura, Masahiko Ichioka, Hajime Goto, Daisuke Kurai, Takeshi Saraya, Mitsuhiro Okazaki, Koichiro Yoshida, Takashi Yoshida, Hiroki Tsukada, Yumiko Imai, Yasuo Honma, Toshinobu Yamamoto, Atsuro Kawai, Hiroshige Mikamo, Yoshio Takesue, Yasunao Wada, Takeyuki Miyara, Hirofumi Toda, Noriko Mitsuno, Yasunori Fujikawa, Hirokazu Nakajima, Shuichi Kubo, Yoshio Ohta, Keiichi Mikasa, Kei Kasahara, Akira Koizumi, Reiko Sano, Shinichi Yagi, Mariko Takaya, Yukinori Kurokawa, Nobuchika Kusano, Eiichiro Mihara, Motoko Nose, Masao Kuwabara, Yoshihiro Fujiue, Toshiyuki Ishimaru, Nobuo Matsubara, Yuji Kawasaki, Hirokazu Tokuyasu, Kayoko Masui, Masamitsu Kido, Toshiyuki Ota, Junichi Honda, Junichi Kadota, Kazufumi Hiramatsu, Yosuke Aoki, Zenzo Nagasawa, Katsunori Yanagihara, Jiro Fujita, Masao Tateyama, Kyoichi Totsuka

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of 1,097 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 987 strains (189 Staphylococcus aureus, 211 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 187 Haemophilus influenzae, 106 Moraxella catarrhalis, 126 Klebsiella pneumoniae, and 162 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including a ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). The incidence of methicillin-resistant S. aureus (MRSA) was as high as 59.8%, and those of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) were 35.5 and 11.8%, respectively. Among H. influenzae, 13.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 26.7% to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.3% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5%) of β-lactamase-producing strains was suspected in Moraxella catarrhalis isolates. Four (3.2%) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5%) of P. aeruginosa were found to be metallo β-lactamase- producing strains, including three (1.9%) suspected multidrug-resistant strains showing resistance to imipenem, amikacin, and ciprofloxacin. Continual national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.

Original languageEnglish
Pages (from-to)510-523
Number of pages14
JournalJournal of Infection and Chemotherapy
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Penicillins
Moraxella (Branhamella) catarrhalis
Drug Therapy
meropenem
Haemophilus influenzae
Klebsiella pneumoniae
Streptococcus pneumoniae
Pseudomonas aeruginosa
Ketolides
Monobactams
Lincosamides
Oxazolidinones
Lactams
Carbapenems
Amikacin
Glycopeptides
Imipenem
Streptococcus pyogenes
Fluoroquinolones
Macrolides

Keywords

  • Resistance
  • Respiratory tract infection
  • Surveillance
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2008 : General view of the pathogens' antibacterial susceptibility. / Niki, Yoshihito; Hanaki, Hideaki; Matsumoto, Tetsuya; Yagisawa, Morimasa; Kohno, Shigeru; Aoki, Nobuki; Watanabe, Akira; Sato, Junko; Hattori, Rikizo; Koashi, Naoto; Terada, Michinori; Kozuki, Tsuneo; Maruo, Akinori; Morita, Kohei; Ogasawara, Kazuhiko; Takahashi, Yoshisaburo; Matsuda, Kenji; Nakanishi, Kunio; Sunakawa, Keisuke; Takeuchi, Kenichi; Fujimura, Seiichi; Takeda, Hiroaki; Ikeda, Hideki; Sato, Naohito; Niitsuma, Katsunao; Saito, Miwako; Koshiba, Shizuko; Kaneko, Michiyo; Miki, Makoto; Nakanowatari, Susumu; Takahashi, Hiroshi; Utagawa, Mutsuko; Nishiya, Hajime; Kawakami, Sayoko; Aoki, Yasuko; Chonabayashi, Naohiko; Sugiura, Hideko; Ichioka, Masahiko; Goto, Hajime; Kurai, Daisuke; Saraya, Takeshi; Okazaki, Mitsuhiro; Yoshida, Koichiro; Yoshida, Takashi; Tsukada, Hiroki; Imai, Yumiko; Honma, Yasuo; Yamamoto, Toshinobu; Kawai, Atsuro; Mikamo, Hiroshige; Takesue, Yoshio; Wada, Yasunao; Miyara, Takeyuki; Toda, Hirofumi; Mitsuno, Noriko; Fujikawa, Yasunori; Nakajima, Hirokazu; Kubo, Shuichi; Ohta, Yoshio; Mikasa, Keiichi; Kasahara, Kei; Koizumi, Akira; Sano, Reiko; Yagi, Shinichi; Takaya, Mariko; Kurokawa, Yukinori; Kusano, Nobuchika; Mihara, Eiichiro; Nose, Motoko; Kuwabara, Masao; Fujiue, Yoshihiro; Ishimaru, Toshiyuki; Matsubara, Nobuo; Kawasaki, Yuji; Tokuyasu, Hirokazu; Masui, Kayoko; Kido, Masamitsu; Ota, Toshiyuki; Honda, Junichi; Kadota, Junichi; Hiramatsu, Kazufumi; Aoki, Yosuke; Nagasawa, Zenzo; Yanagihara, Katsunori; Fujita, Jiro; Tateyama, Masao; Totsuka, Kyoichi.

In: Journal of Infection and Chemotherapy, Vol. 17, No. 4, 08.2011, p. 510-523.

Research output: Contribution to journalArticle

Niki, Y, Hanaki, H, Matsumoto, T, Yagisawa, M, Kohno, S, Aoki, N, Watanabe, A, Sato, J, Hattori, R, Koashi, N, Terada, M, Kozuki, T, Maruo, A, Morita, K, Ogasawara, K, Takahashi, Y, Matsuda, K, Nakanishi, K, Sunakawa, K, Takeuchi, K, Fujimura, S, Takeda, H, Ikeda, H, Sato, N, Niitsuma, K, Saito, M, Koshiba, S, Kaneko, M, Miki, M, Nakanowatari, S, Takahashi, H, Utagawa, M, Nishiya, H, Kawakami, S, Aoki, Y, Chonabayashi, N, Sugiura, H, Ichioka, M, Goto, H, Kurai, D, Saraya, T, Okazaki, M, Yoshida, K, Yoshida, T, Tsukada, H, Imai, Y, Honma, Y, Yamamoto, T, Kawai, A, Mikamo, H, Takesue, Y, Wada, Y, Miyara, T, Toda, H, Mitsuno, N, Fujikawa, Y, Nakajima, H, Kubo, S, Ohta, Y, Mikasa, K, Kasahara, K, Koizumi, A, Sano, R, Yagi, S, Takaya, M, Kurokawa, Y, Kusano, N, Mihara, E, Nose, M, Kuwabara, M, Fujiue, Y, Ishimaru, T, Matsubara, N, Kawasaki, Y, Tokuyasu, H, Masui, K, Kido, M, Ota, T, Honda, J, Kadota, J, Hiramatsu, K, Aoki, Y, Nagasawa, Z, Yanagihara, K, Fujita, J, Tateyama, M & Totsuka, K 2011, 'Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2008: General view of the pathogens' antibacterial susceptibility', Journal of Infection and Chemotherapy, vol. 17, no. 4, pp. 510-523. https://doi.org/10.1007/s10156-011-0214-5
Niki, Yoshihito ; Hanaki, Hideaki ; Matsumoto, Tetsuya ; Yagisawa, Morimasa ; Kohno, Shigeru ; Aoki, Nobuki ; Watanabe, Akira ; Sato, Junko ; Hattori, Rikizo ; Koashi, Naoto ; Terada, Michinori ; Kozuki, Tsuneo ; Maruo, Akinori ; Morita, Kohei ; Ogasawara, Kazuhiko ; Takahashi, Yoshisaburo ; Matsuda, Kenji ; Nakanishi, Kunio ; Sunakawa, Keisuke ; Takeuchi, Kenichi ; Fujimura, Seiichi ; Takeda, Hiroaki ; Ikeda, Hideki ; Sato, Naohito ; Niitsuma, Katsunao ; Saito, Miwako ; Koshiba, Shizuko ; Kaneko, Michiyo ; Miki, Makoto ; Nakanowatari, Susumu ; Takahashi, Hiroshi ; Utagawa, Mutsuko ; Nishiya, Hajime ; Kawakami, Sayoko ; Aoki, Yasuko ; Chonabayashi, Naohiko ; Sugiura, Hideko ; Ichioka, Masahiko ; Goto, Hajime ; Kurai, Daisuke ; Saraya, Takeshi ; Okazaki, Mitsuhiro ; Yoshida, Koichiro ; Yoshida, Takashi ; Tsukada, Hiroki ; Imai, Yumiko ; Honma, Yasuo ; Yamamoto, Toshinobu ; Kawai, Atsuro ; Mikamo, Hiroshige ; Takesue, Yoshio ; Wada, Yasunao ; Miyara, Takeyuki ; Toda, Hirofumi ; Mitsuno, Noriko ; Fujikawa, Yasunori ; Nakajima, Hirokazu ; Kubo, Shuichi ; Ohta, Yoshio ; Mikasa, Keiichi ; Kasahara, Kei ; Koizumi, Akira ; Sano, Reiko ; Yagi, Shinichi ; Takaya, Mariko ; Kurokawa, Yukinori ; Kusano, Nobuchika ; Mihara, Eiichiro ; Nose, Motoko ; Kuwabara, Masao ; Fujiue, Yoshihiro ; Ishimaru, Toshiyuki ; Matsubara, Nobuo ; Kawasaki, Yuji ; Tokuyasu, Hirokazu ; Masui, Kayoko ; Kido, Masamitsu ; Ota, Toshiyuki ; Honda, Junichi ; Kadota, Junichi ; Hiramatsu, Kazufumi ; Aoki, Yosuke ; Nagasawa, Zenzo ; Yanagihara, Katsunori ; Fujita, Jiro ; Tateyama, Masao ; Totsuka, Kyoichi. / Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2008 : General view of the pathogens' antibacterial susceptibility. In: Journal of Infection and Chemotherapy. 2011 ; Vol. 17, No. 4. pp. 510-523.
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abstract = "For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of 1,097 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 987 strains (189 Staphylococcus aureus, 211 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 187 Haemophilus influenzae, 106 Moraxella catarrhalis, 126 Klebsiella pneumoniae, and 162 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including a ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). The incidence of methicillin-resistant S. aureus (MRSA) was as high as 59.8{\%}, and those of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) were 35.5 and 11.8{\%}, respectively. Among H. influenzae, 13.9{\%} of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 26.7{\%} to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.3{\%} to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5{\%}) of β-lactamase-producing strains was suspected in Moraxella catarrhalis isolates. Four (3.2{\%}) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5{\%}) of P. aeruginosa were found to be metallo β-lactamase- producing strains, including three (1.9{\%}) suspected multidrug-resistant strains showing resistance to imipenem, amikacin, and ciprofloxacin. Continual national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.",
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TY - JOUR

T1 - Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2008

T2 - General view of the pathogens' antibacterial susceptibility

AU - Niki, Yoshihito

AU - Hanaki, Hideaki

AU - Matsumoto, Tetsuya

AU - Yagisawa, Morimasa

AU - Kohno, Shigeru

AU - Aoki, Nobuki

AU - Watanabe, Akira

AU - Sato, Junko

AU - Hattori, Rikizo

AU - Koashi, Naoto

AU - Terada, Michinori

AU - Kozuki, Tsuneo

AU - Maruo, Akinori

AU - Morita, Kohei

AU - Ogasawara, Kazuhiko

AU - Takahashi, Yoshisaburo

AU - Matsuda, Kenji

AU - Nakanishi, Kunio

AU - Sunakawa, Keisuke

AU - Takeuchi, Kenichi

AU - Fujimura, Seiichi

AU - Takeda, Hiroaki

AU - Ikeda, Hideki

AU - Sato, Naohito

AU - Niitsuma, Katsunao

AU - Saito, Miwako

AU - Koshiba, Shizuko

AU - Kaneko, Michiyo

AU - Miki, Makoto

AU - Nakanowatari, Susumu

AU - Takahashi, Hiroshi

AU - Utagawa, Mutsuko

AU - Nishiya, Hajime

AU - Kawakami, Sayoko

AU - Aoki, Yasuko

AU - Chonabayashi, Naohiko

AU - Sugiura, Hideko

AU - Ichioka, Masahiko

AU - Goto, Hajime

AU - Kurai, Daisuke

AU - Saraya, Takeshi

AU - Okazaki, Mitsuhiro

AU - Yoshida, Koichiro

AU - Yoshida, Takashi

AU - Tsukada, Hiroki

AU - Imai, Yumiko

AU - Honma, Yasuo

AU - Yamamoto, Toshinobu

AU - Kawai, Atsuro

AU - Mikamo, Hiroshige

AU - Takesue, Yoshio

AU - Wada, Yasunao

AU - Miyara, Takeyuki

AU - Toda, Hirofumi

AU - Mitsuno, Noriko

AU - Fujikawa, Yasunori

AU - Nakajima, Hirokazu

AU - Kubo, Shuichi

AU - Ohta, Yoshio

AU - Mikasa, Keiichi

AU - Kasahara, Kei

AU - Koizumi, Akira

AU - Sano, Reiko

AU - Yagi, Shinichi

AU - Takaya, Mariko

AU - Kurokawa, Yukinori

AU - Kusano, Nobuchika

AU - Mihara, Eiichiro

AU - Nose, Motoko

AU - Kuwabara, Masao

AU - Fujiue, Yoshihiro

AU - Ishimaru, Toshiyuki

AU - Matsubara, Nobuo

AU - Kawasaki, Yuji

AU - Tokuyasu, Hirokazu

AU - Masui, Kayoko

AU - Kido, Masamitsu

AU - Ota, Toshiyuki

AU - Honda, Junichi

AU - Kadota, Junichi

AU - Hiramatsu, Kazufumi

AU - Aoki, Yosuke

AU - Nagasawa, Zenzo

AU - Yanagihara, Katsunori

AU - Fujita, Jiro

AU - Tateyama, Masao

AU - Totsuka, Kyoichi

PY - 2011/8

Y1 - 2011/8

N2 - For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of 1,097 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 987 strains (189 Staphylococcus aureus, 211 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 187 Haemophilus influenzae, 106 Moraxella catarrhalis, 126 Klebsiella pneumoniae, and 162 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including a ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). The incidence of methicillin-resistant S. aureus (MRSA) was as high as 59.8%, and those of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) were 35.5 and 11.8%, respectively. Among H. influenzae, 13.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 26.7% to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.3% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5%) of β-lactamase-producing strains was suspected in Moraxella catarrhalis isolates. Four (3.2%) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5%) of P. aeruginosa were found to be metallo β-lactamase- producing strains, including three (1.9%) suspected multidrug-resistant strains showing resistance to imipenem, amikacin, and ciprofloxacin. Continual national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.

AB - For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of 1,097 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 987 strains (189 Staphylococcus aureus, 211 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 187 Haemophilus influenzae, 106 Moraxella catarrhalis, 126 Klebsiella pneumoniae, and 162 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including a ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). The incidence of methicillin-resistant S. aureus (MRSA) was as high as 59.8%, and those of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) were 35.5 and 11.8%, respectively. Among H. influenzae, 13.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 26.7% to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.3% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5%) of β-lactamase-producing strains was suspected in Moraxella catarrhalis isolates. Four (3.2%) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5%) of P. aeruginosa were found to be metallo β-lactamase- producing strains, including three (1.9%) suspected multidrug-resistant strains showing resistance to imipenem, amikacin, and ciprofloxacin. Continual national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.

KW - Resistance

KW - Respiratory tract infection

KW - Surveillance

KW - Susceptibility

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