Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007

General view of the pathogens' antibacterial susceptibility

Y. Niki, H. Hanaki, T. Matsumoto, M. Yagisawa, S. Kohno, N. Aoki, A. Watanabe, J. Sato, R. Hattori, M. Terada, N. Koashi, T. Kozuki, A. Maruo, K. Morita, K. Ogasawara, Y. Takahashi, J. Watanabe, K. Takeuchi, S. Fujimura, H. Takeda & 81 others H. Ikeda, N. Sato, K. Niitsuma, M. Saito, S. Koshiba, M. Kaneko, M. Miki, S. Nakanowatari, Y. Honda, J. Chiba, H. Takahashi, M. Utagawa, T. Kondo, A. Kawana, H. Konosaki, Y. Aoki, H. Ueda, H. Sugiura, M. Ichioka, H. Goto, D. Kurai, M. Okazaki, K. Yoshida, T. Yoshida, Y. Tanabe, S. Kobayashi, M. Okada, H. Tsukada, Y. Imai, Y. Honma, K. Nishikawa, T. Yamamoto, A. Kawai, T. Kashiwabara, Y. Takesue, Y. Wada, K. Nakajima, T. Miyara, H. Toda, N. Mitsuno, H. Sugimura, S. Yoshioka, M. Kurokawa, Y. Munekawa, H. Nakajima, S. Kubo, Y. Ohta, K. Mikasa, K. Maeda, K. Kasahara, A. Koizumi, R. Sano, S. Yagi, M. Takaya, Y. Kurokawa, Nobuchika Kusano, E. Mihara, M. Kuwabara, Y. Fujiue, T. Ishimaru, N. Matsubara, Y. Kawasaki, H. Tokuyasu, K. Masui, K. Negayama, N. Ueda, M. Ishimaru, Y. Nakanishi, M. Fujita, J. Honda, J. Kadota, K. Hiramatsu, Y. Aoki, Z. Nagasawa, M. Suga, H. Muranaka, K. Yanagihara, J. Fujita, M. Tateyama, K. Sunakawa, K. Totsuka

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

For the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in Japan, the Japanese Society of Chemotherapy conducted their second year survey, during the period from January to August, 2007. A total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. Susceptibility testing was evaluable for 1108 strains (226 Staphylococcus aureus, 257 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 206 Haemophilus influenzae, 120 Moraxella catarrhalis, 122 Klebsiella pneumoniae, and 171 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standards Institute (CLSI). The incidence of methicillinresistant Staphylococcus aureus (MRSA) was high, at 59.7%, and the incidences of penicillin-intermediateresistant and -resistant Streptococcus pneumoniae (PISP and PRSP) were 30.4% and 5.1%, respectively. Among Haemophilus influenzae strains, 19.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately-resistant (BLNAI), 29.1% to be β-lactamasenon-producing ABPC-resistant (BLNAR), and 6.7% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae was not isolated. Two isolates (1.2%) of Pseudomonas aeruginosa were found to be metallo-β-lactamase-producing strains, including one (0.6%) suspected multidrug-resistant strain showing resistance to imipenem, amikacin, and ciprofloxacin. These data will be a useful reference for future periodic surveillance studies and for investigations to control resistant infections as well. Continued surveillance is required to prevent the further spread of these antimicrobial resistances.

Original languageEnglish
Pages (from-to)156-167
Number of pages12
JournalJournal of Infection and Chemotherapy
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Penicillins
meropenem
Haemophilus influenzae
Klebsiella pneumoniae
Streptococcus pneumoniae
Drug Therapy
Pseudomonas aeruginosa
Staphylococcus aureus
Ketolides
Monobactams
Lincosamides
Oxazolidinones
Moraxella (Branhamella) catarrhalis
Lactams
Carbapenems
Amikacin
Glycopeptides
Imipenem
Streptococcus pyogenes
Fluoroquinolones

Keywords

  • Resistance
  • Respiratory tract nfection
  • Surveillance
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007 : General view of the pathogens' antibacterial susceptibility. / Niki, Y.; Hanaki, H.; Matsumoto, T.; Yagisawa, M.; Kohno, S.; Aoki, N.; Watanabe, A.; Sato, J.; Hattori, R.; Terada, M.; Koashi, N.; Kozuki, T.; Maruo, A.; Morita, K.; Ogasawara, K.; Takahashi, Y.; Watanabe, J.; Takeuchi, K.; Fujimura, S.; Takeda, H.; Ikeda, H.; Sato, N.; Niitsuma, K.; Saito, M.; Koshiba, S.; Kaneko, M.; Miki, M.; Nakanowatari, S.; Honda, Y.; Chiba, J.; Takahashi, H.; Utagawa, M.; Kondo, T.; Kawana, A.; Konosaki, H.; Aoki, Y.; Ueda, H.; Sugiura, H.; Ichioka, M.; Goto, H.; Kurai, D.; Okazaki, M.; Yoshida, K.; Yoshida, T.; Tanabe, Y.; Kobayashi, S.; Okada, M.; Tsukada, H.; Imai, Y.; Honma, Y.; Nishikawa, K.; Yamamoto, T.; Kawai, A.; Kashiwabara, T.; Takesue, Y.; Wada, Y.; Nakajima, K.; Miyara, T.; Toda, H.; Mitsuno, N.; Sugimura, H.; Yoshioka, S.; Kurokawa, M.; Munekawa, Y.; Nakajima, H.; Kubo, S.; Ohta, Y.; Mikasa, K.; Maeda, K.; Kasahara, K.; Koizumi, A.; Sano, R.; Yagi, S.; Takaya, M.; Kurokawa, Y.; Kusano, Nobuchika; Mihara, E.; Kuwabara, M.; Fujiue, Y.; Ishimaru, T.; Matsubara, N.; Kawasaki, Y.; Tokuyasu, H.; Masui, K.; Negayama, K.; Ueda, N.; Ishimaru, M.; Nakanishi, Y.; Fujita, M.; Honda, J.; Kadota, J.; Hiramatsu, K.; Aoki, Y.; Nagasawa, Z.; Suga, M.; Muranaka, H.; Yanagihara, K.; Fujita, J.; Tateyama, M.; Sunakawa, K.; Totsuka, K.

In: Journal of Infection and Chemotherapy, Vol. 15, No. 3, 06.2009, p. 156-167.

Research output: Contribution to journalArticle

Niki, Y, Hanaki, H, Matsumoto, T, Yagisawa, M, Kohno, S, Aoki, N, Watanabe, A, Sato, J, Hattori, R, Terada, M, Koashi, N, Kozuki, T, Maruo, A, Morita, K, Ogasawara, K, Takahashi, Y, Watanabe, J, Takeuchi, K, Fujimura, S, Takeda, H, Ikeda, H, Sato, N, Niitsuma, K, Saito, M, Koshiba, S, Kaneko, M, Miki, M, Nakanowatari, S, Honda, Y, Chiba, J, Takahashi, H, Utagawa, M, Kondo, T, Kawana, A, Konosaki, H, Aoki, Y, Ueda, H, Sugiura, H, Ichioka, M, Goto, H, Kurai, D, Okazaki, M, Yoshida, K, Yoshida, T, Tanabe, Y, Kobayashi, S, Okada, M, Tsukada, H, Imai, Y, Honma, Y, Nishikawa, K, Yamamoto, T, Kawai, A, Kashiwabara, T, Takesue, Y, Wada, Y, Nakajima, K, Miyara, T, Toda, H, Mitsuno, N, Sugimura, H, Yoshioka, S, Kurokawa, M, Munekawa, Y, Nakajima, H, Kubo, S, Ohta, Y, Mikasa, K, Maeda, K, Kasahara, K, Koizumi, A, Sano, R, Yagi, S, Takaya, M, Kurokawa, Y, Kusano, N, Mihara, E, Kuwabara, M, Fujiue, Y, Ishimaru, T, Matsubara, N, Kawasaki, Y, Tokuyasu, H, Masui, K, Negayama, K, Ueda, N, Ishimaru, M, Nakanishi, Y, Fujita, M, Honda, J, Kadota, J, Hiramatsu, K, Aoki, Y, Nagasawa, Z, Suga, M, Muranaka, H, Yanagihara, K, Fujita, J, Tateyama, M, Sunakawa, K & Totsuka, K 2009, 'Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007: General view of the pathogens' antibacterial susceptibility', Journal of Infection and Chemotherapy, vol. 15, no. 3, pp. 156-167. https://doi.org/10.1007/s10156-009-0674-z
Niki, Y. ; Hanaki, H. ; Matsumoto, T. ; Yagisawa, M. ; Kohno, S. ; Aoki, N. ; Watanabe, A. ; Sato, J. ; Hattori, R. ; Terada, M. ; Koashi, N. ; Kozuki, T. ; Maruo, A. ; Morita, K. ; Ogasawara, K. ; Takahashi, Y. ; Watanabe, J. ; Takeuchi, K. ; Fujimura, S. ; Takeda, H. ; Ikeda, H. ; Sato, N. ; Niitsuma, K. ; Saito, M. ; Koshiba, S. ; Kaneko, M. ; Miki, M. ; Nakanowatari, S. ; Honda, Y. ; Chiba, J. ; Takahashi, H. ; Utagawa, M. ; Kondo, T. ; Kawana, A. ; Konosaki, H. ; Aoki, Y. ; Ueda, H. ; Sugiura, H. ; Ichioka, M. ; Goto, H. ; Kurai, D. ; Okazaki, M. ; Yoshida, K. ; Yoshida, T. ; Tanabe, Y. ; Kobayashi, S. ; Okada, M. ; Tsukada, H. ; Imai, Y. ; Honma, Y. ; Nishikawa, K. ; Yamamoto, T. ; Kawai, A. ; Kashiwabara, T. ; Takesue, Y. ; Wada, Y. ; Nakajima, K. ; Miyara, T. ; Toda, H. ; Mitsuno, N. ; Sugimura, H. ; Yoshioka, S. ; Kurokawa, M. ; Munekawa, Y. ; Nakajima, H. ; Kubo, S. ; Ohta, Y. ; Mikasa, K. ; Maeda, K. ; Kasahara, K. ; Koizumi, A. ; Sano, R. ; Yagi, S. ; Takaya, M. ; Kurokawa, Y. ; Kusano, Nobuchika ; Mihara, E. ; Kuwabara, M. ; Fujiue, Y. ; Ishimaru, T. ; Matsubara, N. ; Kawasaki, Y. ; Tokuyasu, H. ; Masui, K. ; Negayama, K. ; Ueda, N. ; Ishimaru, M. ; Nakanishi, Y. ; Fujita, M. ; Honda, J. ; Kadota, J. ; Hiramatsu, K. ; Aoki, Y. ; Nagasawa, Z. ; Suga, M. ; Muranaka, H. ; Yanagihara, K. ; Fujita, J. ; Tateyama, M. ; Sunakawa, K. ; Totsuka, K. / Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007 : General view of the pathogens' antibacterial susceptibility. In: Journal of Infection and Chemotherapy. 2009 ; Vol. 15, No. 3. pp. 156-167.
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abstract = "For the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in Japan, the Japanese Society of Chemotherapy conducted their second year survey, during the period from January to August, 2007. A total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. Susceptibility testing was evaluable for 1108 strains (226 Staphylococcus aureus, 257 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 206 Haemophilus influenzae, 120 Moraxella catarrhalis, 122 Klebsiella pneumoniae, and 171 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standards Institute (CLSI). The incidence of methicillinresistant Staphylococcus aureus (MRSA) was high, at 59.7{\%}, and the incidences of penicillin-intermediateresistant and -resistant Streptococcus pneumoniae (PISP and PRSP) were 30.4{\%} and 5.1{\%}, respectively. Among Haemophilus influenzae strains, 19.9{\%} of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately-resistant (BLNAI), 29.1{\%} to be β-lactamasenon-producing ABPC-resistant (BLNAR), and 6.7{\%} to be β-lactamase-producing ABPC-resistant (BLPAR) strains. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae was not isolated. Two isolates (1.2{\%}) of Pseudomonas aeruginosa were found to be metallo-β-lactamase-producing strains, including one (0.6{\%}) suspected multidrug-resistant strain showing resistance to imipenem, amikacin, and ciprofloxacin. These data will be a useful reference for future periodic surveillance studies and for investigations to control resistant infections as well. Continued surveillance is required to prevent the further spread of these antimicrobial resistances.",
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author = "Y. Niki and H. Hanaki and T. Matsumoto and M. Yagisawa and S. Kohno and N. Aoki and A. Watanabe and J. Sato and R. Hattori and M. Terada and N. Koashi and T. Kozuki and A. Maruo and K. Morita and K. Ogasawara and Y. Takahashi and J. Watanabe and K. Takeuchi and S. Fujimura and H. Takeda and H. Ikeda and N. Sato and K. Niitsuma and M. Saito and S. Koshiba and M. Kaneko and M. Miki and S. Nakanowatari and Y. Honda and J. Chiba and H. Takahashi and M. Utagawa and T. Kondo and A. Kawana and H. Konosaki and Y. Aoki and H. Ueda and H. Sugiura and M. Ichioka and H. Goto and D. Kurai and M. Okazaki and K. Yoshida and T. Yoshida and Y. Tanabe and S. Kobayashi and M. Okada and H. Tsukada and Y. Imai and Y. Honma and K. Nishikawa and T. Yamamoto and A. Kawai and T. Kashiwabara and Y. Takesue and Y. Wada and K. Nakajima and T. Miyara and H. Toda and N. Mitsuno and H. Sugimura and S. Yoshioka and M. Kurokawa and Y. Munekawa and H. Nakajima and S. Kubo and Y. Ohta and K. Mikasa and K. Maeda and K. Kasahara and A. Koizumi and R. Sano and S. Yagi and M. Takaya and Y. Kurokawa and Nobuchika Kusano and E. Mihara and M. Kuwabara and Y. Fujiue and T. Ishimaru and N. Matsubara and Y. Kawasaki and H. Tokuyasu and K. Masui and K. Negayama and N. Ueda and M. Ishimaru and Y. Nakanishi and M. Fujita and J. Honda and J. Kadota and K. Hiramatsu and Y. Aoki and Z. Nagasawa and M. Suga and H. Muranaka and K. Yanagihara and J. Fujita and M. Tateyama and K. Sunakawa and K. Totsuka",
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month = "6",
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language = "English",
volume = "15",
pages = "156--167",
journal = "Journal of Infection and Chemotherapy",
issn = "1341-321X",
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TY - JOUR

T1 - Nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007

T2 - General view of the pathogens' antibacterial susceptibility

AU - Niki, Y.

AU - Hanaki, H.

AU - Matsumoto, T.

AU - Yagisawa, M.

AU - Kohno, S.

AU - Aoki, N.

AU - Watanabe, A.

AU - Sato, J.

AU - Hattori, R.

AU - Terada, M.

AU - Koashi, N.

AU - Kozuki, T.

AU - Maruo, A.

AU - Morita, K.

AU - Ogasawara, K.

AU - Takahashi, Y.

AU - Watanabe, J.

AU - Takeuchi, K.

AU - Fujimura, S.

AU - Takeda, H.

AU - Ikeda, H.

AU - Sato, N.

AU - Niitsuma, K.

AU - Saito, M.

AU - Koshiba, S.

AU - Kaneko, M.

AU - Miki, M.

AU - Nakanowatari, S.

AU - Honda, Y.

AU - Chiba, J.

AU - Takahashi, H.

AU - Utagawa, M.

AU - Kondo, T.

AU - Kawana, A.

AU - Konosaki, H.

AU - Aoki, Y.

AU - Ueda, H.

AU - Sugiura, H.

AU - Ichioka, M.

AU - Goto, H.

AU - Kurai, D.

AU - Okazaki, M.

AU - Yoshida, K.

AU - Yoshida, T.

AU - Tanabe, Y.

AU - Kobayashi, S.

AU - Okada, M.

AU - Tsukada, H.

AU - Imai, Y.

AU - Honma, Y.

AU - Nishikawa, K.

AU - Yamamoto, T.

AU - Kawai, A.

AU - Kashiwabara, T.

AU - Takesue, Y.

AU - Wada, Y.

AU - Nakajima, K.

AU - Miyara, T.

AU - Toda, H.

AU - Mitsuno, N.

AU - Sugimura, H.

AU - Yoshioka, S.

AU - Kurokawa, M.

AU - Munekawa, Y.

AU - Nakajima, H.

AU - Kubo, S.

AU - Ohta, Y.

AU - Mikasa, K.

AU - Maeda, K.

AU - Kasahara, K.

AU - Koizumi, A.

AU - Sano, R.

AU - Yagi, S.

AU - Takaya, M.

AU - Kurokawa, Y.

AU - Kusano, Nobuchika

AU - Mihara, E.

AU - Kuwabara, M.

AU - Fujiue, Y.

AU - Ishimaru, T.

AU - Matsubara, N.

AU - Kawasaki, Y.

AU - Tokuyasu, H.

AU - Masui, K.

AU - Negayama, K.

AU - Ueda, N.

AU - Ishimaru, M.

AU - Nakanishi, Y.

AU - Fujita, M.

AU - Honda, J.

AU - Kadota, J.

AU - Hiramatsu, K.

AU - Aoki, Y.

AU - Nagasawa, Z.

AU - Suga, M.

AU - Muranaka, H.

AU - Yanagihara, K.

AU - Fujita, J.

AU - Tateyama, M.

AU - Sunakawa, K.

AU - Totsuka, K.

PY - 2009/6

Y1 - 2009/6

N2 - For the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in Japan, the Japanese Society of Chemotherapy conducted their second year survey, during the period from January to August, 2007. A total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. Susceptibility testing was evaluable for 1108 strains (226 Staphylococcus aureus, 257 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 206 Haemophilus influenzae, 120 Moraxella catarrhalis, 122 Klebsiella pneumoniae, and 171 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standards Institute (CLSI). The incidence of methicillinresistant Staphylococcus aureus (MRSA) was high, at 59.7%, and the incidences of penicillin-intermediateresistant and -resistant Streptococcus pneumoniae (PISP and PRSP) were 30.4% and 5.1%, respectively. Among Haemophilus influenzae strains, 19.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately-resistant (BLNAI), 29.1% to be β-lactamasenon-producing ABPC-resistant (BLNAR), and 6.7% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae was not isolated. Two isolates (1.2%) of Pseudomonas aeruginosa were found to be metallo-β-lactamase-producing strains, including one (0.6%) suspected multidrug-resistant strain showing resistance to imipenem, amikacin, and ciprofloxacin. These data will be a useful reference for future periodic surveillance studies and for investigations to control resistant infections as well. Continued surveillance is required to prevent the further spread of these antimicrobial resistances.

AB - For the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in Japan, the Japanese Society of Chemotherapy conducted their second year survey, during the period from January to August, 2007. A total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. Susceptibility testing was evaluable for 1108 strains (226 Staphylococcus aureus, 257 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 206 Haemophilus influenzae, 120 Moraxella catarrhalis, 122 Klebsiella pneumoniae, and 171 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standards Institute (CLSI). The incidence of methicillinresistant Staphylococcus aureus (MRSA) was high, at 59.7%, and the incidences of penicillin-intermediateresistant and -resistant Streptococcus pneumoniae (PISP and PRSP) were 30.4% and 5.1%, respectively. Among Haemophilus influenzae strains, 19.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately-resistant (BLNAI), 29.1% to be β-lactamasenon-producing ABPC-resistant (BLNAR), and 6.7% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae was not isolated. Two isolates (1.2%) of Pseudomonas aeruginosa were found to be metallo-β-lactamase-producing strains, including one (0.6%) suspected multidrug-resistant strain showing resistance to imipenem, amikacin, and ciprofloxacin. These data will be a useful reference for future periodic surveillance studies and for investigations to control resistant infections as well. Continued surveillance is required to prevent the further spread of these antimicrobial resistances.

KW - Resistance

KW - Respiratory tract nfection

KW - Surveillance

KW - Susceptibility

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U2 - 10.1007/s10156-009-0674-z

DO - 10.1007/s10156-009-0674-z

M3 - Article

VL - 15

SP - 156

EP - 167

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

SN - 1341-321X

IS - 3

ER -