Nasal-type natural killer cell lmyphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier

M. Kunisada, Atsuko Adachi, S. Matsumoto, Y. Ogawa, T. Horikawa, K. Iwatsuki

Research output: Contribution to journalArticle

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Abstract

We report a case of an Epstein-Barr virus (EBV)-associated nasal-type natural killer cell lymphoma (NKCL) preceded by benign panniculitis, which arose in a 48-year-old woman with an asymptomatic human T-cell leukemia/lymphoma virus type-1 (HTLV-1) infection. A biopsy of the initial panniculitis lesion demonstrated lobular panniculitis with a germinal center composed of benign mononuclear cells with a phehotype of CD4+CD45RO+CD5sCD3+cCD3ε+ T-cell intracellular antigen-1 (TIA-1)- and granzyme B-. One year after oral prednisolone therapy, the patient developed subcutaneous nodules composed of atypical lymphoid cells with a phenotype of CD4+CD45RO+CD56+sCD3-cCD3ε + (TIA-1)+ and granzyme B+. In the initial panniculitis lesion, neither EBV-encoded RNA (EBER-1) nor clonal proliferation of EBV-infected cells was identified. In later lesions, however, a large number of atypical cells were positive for EBER-1, and a clonal expansion of EBV-infected cells was detected. No clonal rearrangement of T-cell receptor-α, -β, or -γ genes was found in either specimen. This patient was an asymptomatic carrier of human T-cell leukemia/lymphoma virus type-1 (HTLV-1) without clonal integration of proviral HTLV-1 in neither the peripheral blood nor the skin lesions. These observations suggest that EBV-associated NKCL occurred subsequently in the clinical course of benign panniculitis under the influence of immunosuppression caused by prednisolone treatment and HTLV-1 infection.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalInternational Journal of Dermatology
Volume42
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Panniculitis
Deltaretrovirus
Nose
Natural Killer Cells
Human Herpesvirus 4
Granzymes
Virus Diseases
Prednisolone
Lymphoma
T-Lymphocytes
T-Cell Receptor Genes
Antigens
Germinal Center
Immunosuppression
Cell Count
Lymphocytes
Phenotype
Biopsy
Skin
Therapeutics

ASJC Scopus subject areas

  • Dermatology

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Nasal-type natural killer cell lmyphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. / Kunisada, M.; Adachi, Atsuko; Matsumoto, S.; Ogawa, Y.; Horikawa, T.; Iwatsuki, K.

In: International Journal of Dermatology, Vol. 42, No. 9, 01.09.2003, p. 710-714.

Research output: Contribution to journalArticle

Kunisada, M. ; Adachi, Atsuko ; Matsumoto, S. ; Ogawa, Y. ; Horikawa, T. ; Iwatsuki, K. / Nasal-type natural killer cell lmyphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. In: International Journal of Dermatology. 2003 ; Vol. 42, No. 9. pp. 710-714.
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