Nasal and nasal-type natural killer/T-cell lymphoma

S. Hirakawa; M. Kuyama; S. Takahashi; O. Yamasaki; H. Kanzaki; T. Teshima; M. Harada; Y. Ma; T. Kawabata; T. Yoshino; J. Arata

doi:10.1016/S0190-9622(99)70204-5

Nasal and nasal-type natural killer/T-cell lymphoma

S. Hirakawa, M. Kuyama, S. Takahashi, O. Yamasaki, H. Kanzaki, T. Teshima, M. Harada, Y. Ma, T. Kawabata, T. Yoshino, J. Arata

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38 Citations (Scopus)

Abstract

Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple- drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation. The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary.

Original language	English
Pages (from-to)	268-272
Number of pages	5
Journal	Journal of the American Academy of Dermatology
Volume	40
Issue number	2 I
DOIs	https://doi.org/10.1016/S0190-9622(99)70204-5
Publication status	Published - 1999

ASJC Scopus subject areas

Dermatology

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10.1016/S0190-9622(99)70204-5

Cite this

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title = "Nasal and nasal-type natural killer/T-cell lymphoma",

abstract = "Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple- drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation. The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary.",

author = "S. Hirakawa and M. Kuyama and S. Takahashi and O. Yamasaki and H. Kanzaki and T. Teshima and M. Harada and Y. Ma and T. Kawabata and T. Yoshino and J. Arata",

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T1 - Nasal and nasal-type natural killer/T-cell lymphoma

AU - Hirakawa, S.

AU - Kuyama, M.

AU - Takahashi, S.

AU - Yamasaki, O.

AU - Kanzaki, H.

AU - Teshima, T.

AU - Harada, M.

AU - Ma, Y.

AU - Kawabata, T.

AU - Yoshino, T.

AU - Arata, J.

PY - 1999

Y1 - 1999

N2 - Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple- drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation. The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary.

AB - Nasal and nasal-type natural killer (NK)/T-cell lymphomas follow an aggressive course and have a poor prognosis. Recent pathologic studies suggest that the disease is a malignant proliferation of NK cells, which often express CD56. An association with the Epstein-Barr virus has also been reported. Skin involvement occurred in each of the 3 patients studied. Radiation therapy provided some benefit to the patients in the early stages. Conventional chemotherapies were not effective. To overcome this multiple- drug resistance of the tumor cells, cyclosporine and high-dose chemotherapy was combined with peripheral-blood stem-cell transplantation. The average life span from the onset of the disease for our patients was 9.6 months. Further improvement in the management of nasal and nasal-type NK/T-cell lymphomas is necessary.

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IS - 2 I

ER -

Nasal and nasal-type natural killer/T-cell lymphoma

Abstract

ASJC Scopus subject areas

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