Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers

Ryuta Takenaka, Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Masafumi Inoue, Seiji Kawano, Daisuke Tanioka, Takao Tsuzuki, Masayuki Uemura, Nobuya Ohara, Susumu Tominaga, Tomoo Onoda, Kazuhide Yamamoto

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The narrow-band imaging (NBI) system is a novel technology that enhances the visualization of microvasculature and mucosal patterns. The aim of this study was to assess the reliability of the NBI system for esophageal cancer screening in patients with head and neck cancers. METHODS: A total of 142 patients with head and neck squamous cell carcinoma (SCC) were examined by NBI endoscopy, followed by Lugol chromoendoscopy between April 2006 and June 2008 at the Okayama University Hospital, Okayama, Japan. Detection of SCC and high-grade intraepithelial neoplasia (HGIN) was conducted. RESULTS: The median age of the patients was 64 years (range: 29-86 years), and approximately three-fourths of all the patients were male. In total, 21 superficial lesions in 16 patients were detected by NBI endoscopy. Of these, 4 lesions were diagnosed histologically as SCC and 11 lesions as HGIN. An additional 22 Lugol-voiding lesions 5 mm were detected in 19 patients by Lugol chromoendoscopy. Although 1 of these lesions was diagnosed as HGIN, 21 lesions were diagnosed as low-grade intraepithelial neoplasia or lesions without atypical findings. The sensitivity of NBI endoscopy for detecting esophageal SCC and HGIN was 90.9% (95% confidence interval (CI), 58.7-99.8), specificity was 95.4% (95% CI, 90.3-98.3), and accuracy was 95.1% (95% CI, 90.1-98.0). CONCLUSIONS: NBI seems to be useful and reliable for screening for esophageal SCC in patients with head and neck cancers.

Original languageEnglish
Pages (from-to)2942-2948
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume104
Issue number12
DOIs
Publication statusPublished - Dec 2009

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Narrow Band Imaging
Head and Neck Neoplasms
Neoplasms
Endoscopy
Confidence Intervals
Squamous Cell Carcinoma
Esophageal Neoplasms
Microvessels
Early Detection of Cancer
Japan
Technology

ASJC Scopus subject areas

  • Gastroenterology

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Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers. / Takenaka, Ryuta; Kawahara, Yoshiro; Okada, Hiroyuki; Hori, Keisuke; Inoue, Masafumi; Kawano, Seiji; Tanioka, Daisuke; Tsuzuki, Takao; Uemura, Masayuki; Ohara, Nobuya; Tominaga, Susumu; Onoda, Tomoo; Yamamoto, Kazuhide.

In: American Journal of Gastroenterology, Vol. 104, No. 12, 12.2009, p. 2942-2948.

Research output: Contribution to journalArticle

Takenaka, R, Kawahara, Y, Okada, H, Hori, K, Inoue, M, Kawano, S, Tanioka, D, Tsuzuki, T, Uemura, M, Ohara, N, Tominaga, S, Onoda, T & Yamamoto, K 2009, 'Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers', American Journal of Gastroenterology, vol. 104, no. 12, pp. 2942-2948. https://doi.org/10.1038/ajg.2009.426
Takenaka, Ryuta ; Kawahara, Yoshiro ; Okada, Hiroyuki ; Hori, Keisuke ; Inoue, Masafumi ; Kawano, Seiji ; Tanioka, Daisuke ; Tsuzuki, Takao ; Uemura, Masayuki ; Ohara, Nobuya ; Tominaga, Susumu ; Onoda, Tomoo ; Yamamoto, Kazuhide. / Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers. In: American Journal of Gastroenterology. 2009 ; Vol. 104, No. 12. pp. 2942-2948.
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AU - Kawahara, Yoshiro

AU - Okada, Hiroyuki

AU - Hori, Keisuke

AU - Inoue, Masafumi

AU - Kawano, Seiji

AU - Tanioka, Daisuke

AU - Tsuzuki, Takao

AU - Uemura, Masayuki

AU - Ohara, Nobuya

AU - Tominaga, Susumu

AU - Onoda, Tomoo

AU - Yamamoto, Kazuhide

PY - 2009/12

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N2 - OBJECTIVES: The narrow-band imaging (NBI) system is a novel technology that enhances the visualization of microvasculature and mucosal patterns. The aim of this study was to assess the reliability of the NBI system for esophageal cancer screening in patients with head and neck cancers. METHODS: A total of 142 patients with head and neck squamous cell carcinoma (SCC) were examined by NBI endoscopy, followed by Lugol chromoendoscopy between April 2006 and June 2008 at the Okayama University Hospital, Okayama, Japan. Detection of SCC and high-grade intraepithelial neoplasia (HGIN) was conducted. RESULTS: The median age of the patients was 64 years (range: 29-86 years), and approximately three-fourths of all the patients were male. In total, 21 superficial lesions in 16 patients were detected by NBI endoscopy. Of these, 4 lesions were diagnosed histologically as SCC and 11 lesions as HGIN. An additional 22 Lugol-voiding lesions 5 mm were detected in 19 patients by Lugol chromoendoscopy. Although 1 of these lesions was diagnosed as HGIN, 21 lesions were diagnosed as low-grade intraepithelial neoplasia or lesions without atypical findings. The sensitivity of NBI endoscopy for detecting esophageal SCC and HGIN was 90.9% (95% confidence interval (CI), 58.7-99.8), specificity was 95.4% (95% CI, 90.3-98.3), and accuracy was 95.1% (95% CI, 90.1-98.0). CONCLUSIONS: NBI seems to be useful and reliable for screening for esophageal SCC in patients with head and neck cancers.

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