Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction

Kumiko Yoshihara, Yasuhiro Yoshida, Noriyuki Nagaoka, Daisuke Fukegawa, Satoshi Hayakawa, Atsushi Mine, Mariko Nakamura, Shougo Minagi, Akiyoshi Osaka, Kazuomi Suzuki, Bart Van Meerbeek

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction.

Original languageEnglish
Pages (from-to)3573-3582
Number of pages10
JournalActa Biomaterialia
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Molecular interactions
Biocompatible Materials
Biomaterials
Adhesives
Tooth
Monomers
Durapatite
Tissue
Hydroxyapatite
Durability
Dental composites
Degradation
Calcium phosphate
Restoration
Sorption
Calcium
Salts
Nuclear magnetic resonance
X ray diffraction
Water

Keywords

  • Adhesion
  • Dentin
  • Hydroxyapatite
  • Interface
  • Nano

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction. / Yoshihara, Kumiko; Yoshida, Yasuhiro; Nagaoka, Noriyuki; Fukegawa, Daisuke; Hayakawa, Satoshi; Mine, Atsushi; Nakamura, Mariko; Minagi, Shougo; Osaka, Akiyoshi; Suzuki, Kazuomi; Van Meerbeek, Bart.

In: Acta Biomaterialia, Vol. 6, No. 9, 09.2010, p. 3573-3582.

Research output: Contribution to journalArticle

Yoshihara, Kumiko ; Yoshida, Yasuhiro ; Nagaoka, Noriyuki ; Fukegawa, Daisuke ; Hayakawa, Satoshi ; Mine, Atsushi ; Nakamura, Mariko ; Minagi, Shougo ; Osaka, Akiyoshi ; Suzuki, Kazuomi ; Van Meerbeek, Bart. / Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction. In: Acta Biomaterialia. 2010 ; Vol. 6, No. 9. pp. 3573-3582.
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