Nakijiquinones G-I, new sesquiterpenoid quinones from marine sponge

Yohei Takahashi, Takaaki Kubota, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)7561-7564
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number16
DOIs
Publication statusPublished - Aug 15 2008
Externally publishedYes

Keywords

  • Marine sponge
  • Nakijiquinones G-I
  • Sesquiterpenoid quinones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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