Nakijinamines C-E, new heteroaromatic alkaloids from the sponge suberites species

Yohei Takahashi; Takaaki Kubota; Azusa Shibazaki; Tohru Gonoi; Jane Fromont; Jun'Ichi Kobayashi

doi:10.1021/ol2008473

Nakijinamines C-E, new heteroaromatic alkaloids from the sponge suberites species

Yohei Takahashi, Takaaki Kubota, Azusa Shibazaki, Tohru Gonoi, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4′,5′:4,5] benzo[1,2,3-de][1,6]naphthyridine ring system.

Original language	English
Pages (from-to)	3016-3019
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	12
DOIs	https://doi.org/10.1021/ol2008473
Publication status	Published - Jun 17 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4′,5′:4,5] benzo[1,2,3-de][1,6]naphthyridine ring system.",

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AU - Takahashi, Yohei

AU - Kubota, Takaaki

AU - Shibazaki, Azusa

AU - Gonoi, Tohru

AU - Fromont, Jane

AU - Kobayashi, Jun'Ichi

PY - 2011/6/17

Y1 - 2011/6/17

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Nakijinamines C-E, new heteroaromatic alkaloids from the sponge suberites species

Abstract

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