Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4′,5′:4,5] benzo[1,2,3-de][1,6]naphthyridine ring system.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry