Nakijinamines C-E, new heteroaromatic alkaloids from the sponge suberites species

Yohei Takahashi, Takaaki Kubota, Azusa Shibazaki, Tohru Gonoi, Jane Fromont, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4′,5′:4,5] benzo[1,2,3-de][1,6]naphthyridine ring system.

Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalOrganic Letters
Issue number12
Publication statusPublished - Jun 17 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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