Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Atsushi Araki, Takaaki Kubota, Kazuki Aoyama, Yuzuru Mikami, Jane Fromont, Ju N.Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

Original languageEnglish
Pages (from-to)1785-1788
Number of pages4
JournalOrganic Letters
Volume11
Issue number8
DOIs
Publication statusPublished - Apr 16 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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