Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Atsushi Araki; Takaaki Kubota; Kazuki Aoyama; Yuzuru Mikami; Jane Fromont; Ju N.Ichi Kobayashi

doi:10.1021/ol900328c

Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Atsushi Araki, Takaaki Kubota, Kazuki Aoyama, Yuzuru Mikami, Jane Fromont, Ju N.Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

Original language	English
Pages (from-to)	1785-1788
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/ol900328c
Publication status	Published - Apr 16 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol900328c

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abstract = "Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.",

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AU - Araki, Atsushi

AU - Kubota, Takaaki

AU - Aoyama, Kazuki

AU - Mikami, Yuzuru

AU - Fromont, Jane

AU - Kobayashi, Ju N.Ichi

PY - 2009/4/16

Y1 - 2009/4/16

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AB - Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated fromSROkinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.

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Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges agelas sp

Abstract

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