Nagelamides M and N, new bromopyrrole alkaloids from sponge Agelas species

Takaaki Kubota, Atsushi Araki, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Two new bromopyrrole alkaloids, nagelamides M (1) and N (2), have been isolated from an Okinawan marine sponge Agelas species, and the structures and stereochemistry were elucidated from the spectroscopic data. Nagelamide M (1) is a novel bromopyrrole alkaloid possessing a 2-amino-octahydropyrrolo[2,3-d]imidazole ring with a taurine unit, while nagelamide N (2) is a new bromopyrrole alkaloid possessing a 2-amino-tetrahydroimidazole-4-one ring with a taurine unit and 3-(dibromopyrrole-2-carboxamido)propanoic acid moiety. Nagelamides M (1) and N (2) exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)10810-10813
Number of pages4
JournalTetrahedron
Volume64
Issue number48
DOIs
Publication statusPublished - Nov 24 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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