Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species

Atsushi Araki, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


(Chemical Equation Presented) Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.

Original languageEnglish
Pages (from-to)2099-2102
Number of pages4
JournalOrganic Letters
Issue number11
Publication statusPublished - Jun 5 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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