Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species

Atsushi Araki; Takaaki Kubota; Masashi Tsuda; Yuzuru Mikami; Jane Fromont; Jun'ichi Kobayashi

doi:10.1021/ol8003904

Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species

Atsushi Araki, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

(Chemical Equation Presented) Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.

Original language	English
Pages (from-to)	2099-2102
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	11
DOIs	https://doi.org/10.1021/ol8003904
Publication status	Published - Jun 5 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol8003904

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abstract = "(Chemical Equation Presented) Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.",

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T1 - Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species

AU - Araki, Atsushi

AU - Kubota, Takaaki

AU - Tsuda, Masashi

AU - Mikami, Yuzuru

AU - Fromont, Jane

AU - Kobayashi, Jun'ichi

PY - 2008/6/5

Y1 - 2008/6/5

N2 - (Chemical Equation Presented) Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.

AB - (Chemical Equation Presented) Two new dimeric bromopyrrole alkaloids, nagelamides K (1) and L (2), have been isolated from Okinawan marine sponges Agelas species, and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide K (1) is a bromopyrrole alkaloid possessing a rare piperidinoiminoimidazolone ring with an aminoimidazole ring and a taurine unit, while nagelamide L (2) is a unique dimeric bromopyrrole alkaloid containing an ester linkage. Nagelamides K (1) and L (2) exhibited antimicrobial activity.

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Nagelamides K and L, dimeric bromopyrrole alkaloids from sponge Agelas species

Abstract

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