Nagelamide I and 2,2'-Didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge agelas sp

Takahiro Iwai, Takaaki Kubota, Jane Fromont, Junichi Kobayashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole- imidazole alkaloid consisting of two subunits connected with a single bond.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume62
Issue number2
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

Keywords

  • 2-2'-didebromonagelamide B
  • Agelas sp.
  • Dimeric bromopyrrole-imidazole alkaloid
  • Marine sponge
  • Nagelamide I

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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