Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells

Goutarou Katsuno, Hideo K. Takahashi, Hiromi Iwagaki, Kenji Mizuno, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka

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4 Citations (Scopus)


Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number4
Publication statusPublished - Sep 22 2005



  • Interleukin-12
  • Interleukin-18
  • Nafamostat mesilate

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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