Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells

Goutarou Katsuno; Hideo K. Takahashi; Hiromi Iwagaki; Kenji Mizuno; Shuji Mori; Tadashi Yoshino; Masahiro Nishibori; Noriaki Tanaka

doi:10.1254/jphs.SC0050130

Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells

Goutarou Katsuno, Hideo K. Takahashi, Hiromi Iwagaki, Kenji Mizuno, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.

Original language	English
Pages (from-to)	463-466
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	98
Issue number	4
DOIs	https://doi.org/10.1254/jphs.SC0050130
Publication status	Published - 2005

Keywords

Interleukin-12
Interleukin-18
Nafamostat mesilate

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. / Katsuno, Goutarou; Takahashi, Hideo K.; Iwagaki, Hiromi; Mizuno, Kenji; Mori, Shuji; Yoshino, Tadashi ; Nishibori, Masahiro; Tanaka, Noriaki.

In: Journal of Pharmacological Sciences, Vol. 98, No. 4, 2005, p. 463-466.

Research output: Contribution to journal › Article › peer-review

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abstract = "Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.",

keywords = "Interleukin-12, Interleukin-18, Nafamostat mesilate",

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AU - Katsuno, Goutarou

AU - Takahashi, Hideo K.

AU - Iwagaki, Hiromi

AU - Mizuno, Kenji

AU - Mori, Shuji

AU - Yoshino, Tadashi

AU - Nishibori, Masahiro

AU - Tanaka, Noriaki

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AB - Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.

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