TY - JOUR
T1 - Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells
AU - Katsuno, Goutarou
AU - Takahashi, Hideo K.
AU - Iwagaki, Hiromi
AU - Mizuno, Kenji
AU - Mori, Shuji
AU - Yoshino, Tadashi
AU - Nishibori, Masahiro
AU - Tanaka, Noriaki
PY - 2005
Y1 - 2005
N2 - Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
AB - Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
KW - Interleukin-12
KW - Interleukin-18
KW - Nafamostat mesilate
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U2 - 10.1254/jphs.SC0050130
DO - 10.1254/jphs.SC0050130
M3 - Article
C2 - 16093612
AN - SCOPUS:24744434676
VL - 98
SP - 463
EP - 466
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8648
IS - 4
ER -