Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells

Goutarou Katsuno, Hideo K. Takahashi, Hiromi Iwagaki, Kenji Mizuno, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Noriaki Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalJournal of Pharmacological Sciences
Volume98
Issue number4
DOIs
Publication statusPublished - 2005

Fingerprint

Interleukin-18
Interleukin-12
Blood Cells
Cytokines
CD40 Ligand
Intercellular Adhesion Molecule-1
Interferons
Monocytes
Tumor Necrosis Factor-alpha
nafamostat
Antibodies
Pharmaceutical Preparations

Keywords

  • Interleukin-12
  • Interleukin-18
  • Nafamostat mesilate

ASJC Scopus subject areas

  • Pharmacology

Cite this

Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. / Katsuno, Goutarou; Takahashi, Hideo K.; Iwagaki, Hiromi; Mizuno, Kenji; Mori, Shuji; Yoshino, Tadashi; Nishibori, Masahiro; Tanaka, Noriaki.

In: Journal of Pharmacological Sciences, Vol. 98, No. 4, 2005, p. 463-466.

Research output: Contribution to journalArticle

Katsuno, Goutarou ; Takahashi, Hideo K. ; Iwagaki, Hiromi ; Mizuno, Kenji ; Mori, Shuji ; Yoshino, Tadashi ; Nishibori, Masahiro ; Tanaka, Noriaki. / Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. In: Journal of Pharmacological Sciences. 2005 ; Vol. 98, No. 4. pp. 463-466.
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AU - Mori, Shuji

AU - Yoshino, Tadashi

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