Abstract
Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
Original language | English |
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Pages (from-to) | 463-466 |
Number of pages | 4 |
Journal | Journal of Pharmacological Sciences |
Volume | 98 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2005 |
Keywords
- Interleukin-12
- Interleukin-18
- Nafamostat mesilate
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology