NADPH-diaphorase activity in nerves and Schwann cells in the periodontal ligament of rat incisor teeth

Hiroyuki Ichikawa, Tomosada Sugimoto

Research output: Contribution to journalArticle

8 Citations (Scopus)


The lingual portion of the incisor periodontal ligament demonstrated activity for nicotinamide adenosine dinucleotide phosphate (NADPH)- diaphorase. Schwann cells surrounding Ruffini-like endings coexpressed NADPH- diaphorase activity and immunoreactivity for inducible nitric oxide synthase. NADPH-diaphorase-positive nerve fibres which coexpressed immunoreactivity for neuronal nitric oxide synthase were in contact with Schwann cells surrounding Ruffini-like endings or terminated as free nerve endings. Neural NADPH- diaphorase activity could not be found in the tissues covering the labial portion of incisor tooth root. It is possible that nitric oxide in Schwann cells and nerves has functions specific to the incisor periodontal ligament.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalArchives of Oral Biology
Issue number2
Publication statusPublished - Apr 6 1998



  • Free nerve ending
  • Incisor
  • Nicotinamide adenosine dinucleotide phosphate-diaphorase
  • Nitric oxide synthase
  • Periodontal ligament
  • Rat
  • Ruffini-like ending

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this