NACP/α-synuclein, NAC, and β-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: A clinicopathological study of two autopsy cases

O. Yokota, Seishi Terada, Hideki Ishizu, Hiroshi Ujike, Takeshi Ishihara, Hanae Nakashima, Minoru Yasuda, Yoshihiro Kitamura, Kenji Uéda, Fréderic Checler, Shigetoshi Kuroda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Approximately 60% of familial and sporadic Alzheimer's disease (AD) cases manifest Lewy bodies (LBs), of which a major component is α-synuclein. Although the pathogenic role of α-synuclein in AD remains unclear, LB formation might be associated with pathological β-amyloid (Aβ) overproduction. Here, we present the clinical and pathological characteristics of two affected family members from a pedigree with the E184D mutation of presenilin-1. One case presented with typical clinical features of AD, but the other case also developed clinical characteristics of dementia with Lewy bodies (DLB), including visual hallucinations, delusions, and parkinsonism. In both cases, neuropathological examination revealed numerous neurofibrillary tangles and severe Aβ deposition in senile plaques and amyloid angiopathy, in which Aβ42 rather than Aβ40 was predominant. Furthermore, remarkable α-synuclein pathology, including LBs and the accumulation of the non-Aβ component of AD amyloid (NAC) in plaques and astrocytes, was detected only in the case that presented with the symptoms of DLB. These findings suggest that (1) LB pathology can influence the clinical features of familial AD, (2) the E184D mutation of presenilin-1 may be associated with the LB formation through Aβ overproduction, although the process of LB formation is strongly affected by other unknown mechanisms, (3) in neurodegenerative disorders with LBs, there is a common pathophysiological background inducing NAC accumulation in neuritic plaques and astrocytes, and (4) the NAC accumulation in neuritic plaques is modulated by the abnormally aggregated tau protein.

Original languageEnglish
Pages (from-to)637-648
Number of pages12
JournalActa neuropathologica
Volume104
Issue number6
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Astrocyte
  • Familial Alzheimer's disease
  • Non-Aβ component of Alzheimer's disease amyloid
  • α-synuclein
  • β-Amyloid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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