[Na                         +                         ] Increases in Body Fluids Sensed by Central Na                         x                          Induce Sympathetically Mediated Blood Pressure Elevations via H                         +                         -Dependent Activation of ASIC1a

Kengo Nomura; Takeshi Y. Hiyama; Hiraki Sakuta; Takashi Matsuda; Chia Hao Lin; Kenta Kobayashi; Kazuto Kobayashi; Tomoyuki Kuwaki; Kunihiko Takahashi; Shigeyuki Matsui; Masaharu Noda

doi:10.1016/j.neuron.2018.11.017

[Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a

Kengo Nomura, Takeshi Y. Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na ⁺ ] sensing by Na _x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H ⁺ released from Na _x -positive glial cells are primary steps in this process.

Original language	English
Pages (from-to)	60-75.e6
Journal	Neuron
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2018.11.017
Publication status	Published - Jan 2 2019
Externally published	Yes

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Keywords

ASIC channel
blood
blood pressure
body fluid
CSF
Na channel
OVLT
PVN
salt-sensitive hypertension
sodium concentration

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Nomura, K., Hiyama, T. Y., Sakuta, H., Matsuda, T., Lin, C. H., Kobayashi, K., Kobayashi, K., Kuwaki, T., Takahashi, K., Matsui, S., & Noda, M. (2019). [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a Neuron, 101(1), 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

[Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a . / Nomura, Kengo; Hiyama, Takeshi Y.; Sakuta, Hiraki; Matsuda, Takashi; Lin, Chia Hao; Kobayashi, Kenta; Kobayashi, Kazuto; Kuwaki, Tomoyuki; Takahashi, Kunihiko; Matsui, Shigeyuki; Noda, Masaharu.

In: Neuron, Vol. 101, No. 1, 02.01.2019, p. 60-75.e6.

Research output: Contribution to journal › Article

Nomura, K, Hiyama, TY, Sakuta, H, Matsuda, T, Lin, CH, Kobayashi, K, Kobayashi, K, Kuwaki, T, Takahashi, K, Matsui, S & Noda, M 2019, ' [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a ', Neuron, vol. 101, no. 1, pp. 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K et al. [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a Neuron. 2019 Jan 2;101(1):60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

Nomura, Kengo ; Hiyama, Takeshi Y. ; Sakuta, Hiraki ; Matsuda, Takashi ; Lin, Chia Hao ; Kobayashi, Kenta ; Kobayashi, Kazuto ; Kuwaki, Tomoyuki ; Takahashi, Kunihiko ; Matsui, Shigeyuki ; Noda, Masaharu. / [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a In: Neuron. 2019 ; Vol. 101, No. 1. pp. 60-75.e6.

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10.1016/j.neuron.2018.11.017