@article{09888e9fd98c4a2ca0e433e44266fb5b,
title = " [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a ",
abstract = " Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process. ",
keywords = "ASIC channel, CSF, Na channel, OVLT, PVN, blood, blood pressure, body fluid, salt-sensitive hypertension, sodium concentration",
author = "Kengo Nomura and Hiyama, {Takeshi Y.} and Hiraki Sakuta and Takashi Matsuda and Lin, {Chia Hao} and Kenta Kobayashi and Kazuto Kobayashi and Tomoyuki Kuwaki and Kunihiko Takahashi and Shigeyuki Matsui and Masaharu Noda",
note = "Funding Information: We thank K. Deisseroth (Stanford University) for the hChR2(H134R) gene and eNpHR3.0 gene. We also thank F. Vaccarino (Yale University) for the hGFAP-CreER T2 knockin mouse. We thank S. Miura, T. Hashimoto, and Y. Isoshima for their technical assistance and A. Kodama for her secretarial assistance. This work was supported by MEXT/JSPS KAKENHI (grant numbers 24220010 to M.N. and 26893324 and 16K18998 to K.N.), Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency ( CREST , JST to M.N., grant number JPMJCR1754 ), the Japan Agency for Medical Research and Development ( AMED PRIME to T.Y.H., grant number JP17gm0810014 ), the Ichiro Kanehara Foundation (to M.N.), the Takeda Science Foundation (to M.N. and T.Y.H.), the Salt Science Research Foundation (to T.Y.H.), and a Sasakawa Scientific Research Grant from the Japan Science Society (to K.N). This work was also supported by the Cooperative Study Program of the National Institute for Physiological Sciences. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "2",
doi = "10.1016/j.neuron.2018.11.017",
language = "English",
volume = "101",
pages = "60--75.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}