[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a

Kengo Nomura, Takeshi Y. Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.

Original languageEnglish
Pages (from-to)60-75.e6
JournalNeuron
Volume101
Issue number1
DOIs
Publication statusPublished - Jan 2 2019
Externally publishedYes

Fingerprint

Body Fluids
Neuroglia
Blood Pressure
Neurons

Keywords

  • ASIC channel
  • blood
  • blood pressure
  • body fluid
  • CSF
  • Na channel
  • OVLT
  • PVN
  • salt-sensitive hypertension
  • sodium concentration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a . / Nomura, Kengo; Hiyama, Takeshi Y.; Sakuta, Hiraki; Matsuda, Takashi; Lin, Chia Hao; Kobayashi, Kenta; Kobayashi, Kazuto; Kuwaki, Tomoyuki; Takahashi, Kunihiko; Matsui, Shigeyuki; Noda, Masaharu.

In: Neuron, Vol. 101, No. 1, 02.01.2019, p. 60-75.e6.

Research output: Contribution to journalArticle

Nomura, K, Hiyama, TY, Sakuta, H, Matsuda, T, Lin, CH, Kobayashi, K, Kobayashi, K, Kuwaki, T, Takahashi, K, Matsui, S & Noda, M 2019, ' [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a ', Neuron, vol. 101, no. 1, pp. 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017
Nomura, Kengo ; Hiyama, Takeshi Y. ; Sakuta, Hiraki ; Matsuda, Takashi ; Lin, Chia Hao ; Kobayashi, Kenta ; Kobayashi, Kazuto ; Kuwaki, Tomoyuki ; Takahashi, Kunihiko ; Matsui, Shigeyuki ; Noda, Masaharu. / [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a In: Neuron. 2019 ; Vol. 101, No. 1. pp. 60-75.e6.
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