[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a

Kengo Nomura, Takeshi Y. Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.

Original languageEnglish
Pages (from-to)60-75.e6
JournalNeuron
Volume101
Issue number1
DOIs
Publication statusPublished - Jan 2 2019
Externally publishedYes

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Keywords

  • ASIC channel
  • blood
  • blood pressure
  • body fluid
  • CSF
  • Na channel
  • OVLT
  • PVN
  • salt-sensitive hypertension
  • sodium concentration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nomura, K., Hiyama, T. Y., Sakuta, H., Matsuda, T., Lin, C. H., Kobayashi, K., Kobayashi, K., Kuwaki, T., Takahashi, K., Matsui, S., & Noda, M. (2019). [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a Neuron, 101(1), 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017