[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a

Kengo Nomura, Takeshi Y. Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.

Original languageEnglish
Pages (from-to)60-75.e6
JournalNeuron
Volume101
Issue number1
DOIs
Publication statusPublished - Jan 2 2019
Externally publishedYes

Fingerprint

Body Fluids
Neuroglia
Blood Pressure
Neurons

Keywords

  • ASIC channel
  • blood
  • blood pressure
  • body fluid
  • CSF
  • Na channel
  • OVLT
  • PVN
  • salt-sensitive hypertension
  • sodium concentration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a . / Nomura, Kengo; Hiyama, Takeshi Y.; Sakuta, Hiraki; Matsuda, Takashi; Lin, Chia Hao; Kobayashi, Kenta; Kobayashi, Kazuto; Kuwaki, Tomoyuki; Takahashi, Kunihiko; Matsui, Shigeyuki; Noda, Masaharu.

In: Neuron, Vol. 101, No. 1, 02.01.2019, p. 60-75.e6.

Research output: Contribution to journal › Article

Nomura, K, Hiyama, TY, Sakuta, H, Matsuda, T, Lin, CH, Kobayashi, K, Kobayashi, K, Kuwaki, T, Takahashi, K, Matsui, S & Noda, M 2019, ' [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a ', Neuron, vol. 101, no. 1, pp. 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017
Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K et al. [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a Neuron. 2019 Jan 2;101(1):60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017
Nomura, Kengo ; Hiyama, Takeshi Y. ; Sakuta, Hiraki ; Matsuda, Takashi ; Lin, Chia Hao ; Kobayashi, Kenta ; Kobayashi, Kazuto ; Kuwaki, Tomoyuki ; Takahashi, Kunihiko ; Matsui, Shigeyuki ; Noda, Masaharu. / [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a In: Neuron. 2019 ; Vol. 101, No. 1. pp. 60-75.e6.
@article{09888e9fd98c4a2ca0e433e44266fb5b,
title = "[Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a",
abstract = "Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.",
keywords = "ASIC channel, blood, blood pressure, body fluid, CSF, Na channel, OVLT, PVN, salt-sensitive hypertension, sodium concentration",
author = "Kengo Nomura and Hiyama, {Takeshi Y.} and Hiraki Sakuta and Takashi Matsuda and Lin, {Chia Hao} and Kenta Kobayashi and Kazuto Kobayashi and Tomoyuki Kuwaki and Kunihiko Takahashi and Shigeyuki Matsui and Masaharu Noda",
year = "2019",
month = "1",
day = "2",
doi = "10.1016/j.neuron.2018.11.017",
language = "English",
volume = "101",
pages = "60--75.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a

AU - Nomura, Kengo

AU - Hiyama, Takeshi Y.

AU - Sakuta, Hiraki

AU - Matsuda, Takashi

AU - Lin, Chia Hao

AU - Kobayashi, Kenta

AU - Kobayashi, Kazuto

AU - Kuwaki, Tomoyuki

AU - Takahashi, Kunihiko

AU - Matsui, Shigeyuki

AU - Noda, Masaharu

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.

AB - Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process.

KW - ASIC channel

KW - blood

KW - blood pressure

KW - body fluid

KW - CSF

KW - Na channel

KW - OVLT

KW - PVN

KW - salt-sensitive hypertension

KW - sodium concentration

UR - http://www.scopus.com/inward/record.url?scp=85058477461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058477461&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.11.017

DO - 10.1016/j.neuron.2018.11.017

M3 - Article

C2 - 30503172

AN - SCOPUS:85058477461

VL - 101

SP - 60-75.e6

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 1

ER -

Access to Document