@article{09888e9fd98c4a2ca0e433e44266fb5b,
title = " [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a ",
abstract = " Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process. ",
keywords = "ASIC channel, CSF, Na channel, OVLT, PVN, blood, blood pressure, body fluid, salt-sensitive hypertension, sodium concentration",
author = "Kengo Nomura and Hiyama, {Takeshi Y.} and Hiraki Sakuta and Takashi Matsuda and Lin, {Chia Hao} and Kenta Kobayashi and Kazuto Kobayashi and Tomoyuki Kuwaki and Kunihiko Takahashi and Shigeyuki Matsui and Masaharu Noda",
note = "Funding Information: We thank K. Deisseroth (Stanford University) for the hChR2(H134R) gene and eNpHR3.0 gene. We also thank F. Vaccarino (Yale University) for the hGFAP-CreERT2 knockin mouse. We thank S. Miura, T. Hashimoto, and Y. Isoshima for their technical assistance and A. Kodama for her secretarial assistance. This work was supported by MEXT/JSPS KAKENHI (grant numbers 24220010 to M.N. and 26893324 and 16K18998 to K.N.), Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency (CREST, JST to M.N., grant number JPMJCR1754), the Japan Agency for Medical Research and Development (AMED PRIME to T.Y.H., grant number JP17gm0810014), the Ichiro Kanehara Foundation (to M.N.), the Takeda Science Foundation (to M.N. and T.Y.H.), the Salt Science Research Foundation (to T.Y.H.), and a Sasakawa Scientific Research Grant from the Japan Science Society (to K.N). This work was also supported by the Cooperative Study Program of the National Institute for Physiological Sciences. Funding Information: We thank K. Deisseroth (Stanford University) for the hChR2(H134R) gene and eNpHR3.0 gene. We also thank F. Vaccarino (Yale University) for the hGFAP-CreER T2 knockin mouse. We thank S. Miura, T. Hashimoto, and Y. Isoshima for their technical assistance and A. Kodama for her secretarial assistance. This work was supported by MEXT/JSPS KAKENHI (grant numbers 24220010 to M.N. and 26893324 and 16K18998 to K.N.), Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency ( CREST , JST to M.N., grant number JPMJCR1754 ), the Japan Agency for Medical Research and Development ( AMED PRIME to T.Y.H., grant number JP17gm0810014 ), the Ichiro Kanehara Foundation (to M.N.), the Takeda Science Foundation (to M.N. and T.Y.H.), the Salt Science Research Foundation (to T.Y.H.), and a Sasakawa Scientific Research Grant from the Japan Science Society (to K.N). This work was also supported by the Cooperative Study Program of the National Institute for Physiological Sciences. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "2",
doi = "10.1016/j.neuron.2018.11.017",
language = "English",
volume = "101",
pages = "60--75.e6",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}