[Na                         +                         ] Increases in Body Fluids Sensed by Central Na                         x                          Induce Sympathetically Mediated Blood Pressure Elevations via H                         +                         -Dependent Activation of ASIC1a

Kengo Nomura; Takeshi Y. Hiyama; Hiraki Sakuta; Takashi Matsuda; Chia Hao Lin; Kenta Kobayashi; Kazuto Kobayashi; Tomoyuki Kuwaki; Kunihiko Takahashi; Shigeyuki Matsui; Masaharu Noda

doi:10.1016/j.neuron.2018.11.017

[Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a

Kengo Nomura, Takeshi Y. Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na ⁺ ] sensing by Na _x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H ⁺ released from Na _x -positive glial cells are primary steps in this process.

Original language	English
Pages (from-to)	60-75.e6
Journal	Neuron
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2018.11.017
Publication status	Published - Jan 2 2019
Externally published	Yes

Keywords

ASIC channel
CSF
Na channel
OVLT
PVN
blood
blood pressure
body fluid
salt-sensitive hypertension
sodium concentration

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.neuron.2018.11.017

Cite this

Nomura, K., Hiyama, T. Y., Sakuta, H., Matsuda, T., Lin, C. H., Kobayashi, K., Kobayashi, K., Kuwaki, T., Takahashi, K., Matsui, S., & Noda, M. (2019). [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a Neuron, 101(1), 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

[Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a . / Nomura, Kengo; Hiyama, Takeshi Y.; Sakuta, Hiraki; Matsuda, Takashi; Lin, Chia Hao; Kobayashi, Kenta; Kobayashi, Kazuto; Kuwaki, Tomoyuki; Takahashi, Kunihiko; Matsui, Shigeyuki; Noda, Masaharu.

In: Neuron, Vol. 101, No. 1, 02.01.2019, p. 60-75.e6.

Research output: Contribution to journal › Article › peer-review

Nomura, K, Hiyama, TY, Sakuta, H, Matsuda, T, Lin, CH, Kobayashi, K, Kobayashi, K, Kuwaki, T, Takahashi, K, Matsui, S & Noda, M 2019, ' [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a ', Neuron, vol. 101, no. 1, pp. 60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

Nomura K, Hiyama TY, Sakuta H, Matsuda T, Lin CH, Kobayashi K et al. [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a Neuron. 2019 Jan 2;101(1):60-75.e6. https://doi.org/10.1016/j.neuron.2018.11.017

Nomura, Kengo ; Hiyama, Takeshi Y. ; Sakuta, Hiraki ; Matsuda, Takashi ; Lin, Chia Hao ; Kobayashi, Kenta ; Kobayashi, Kazuto ; Kuwaki, Tomoyuki ; Takahashi, Kunihiko ; Matsui, Shigeyuki ; Noda, Masaharu. / [Na ⁺ ] Increases in Body Fluids Sensed by Central Na _x Induce Sympathetically Mediated Blood Pressure Elevations via H ⁺ -Dependent Activation of ASIC1a In: Neuron. 2019 ; Vol. 101, No. 1. pp. 60-75.e6.

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title = " [Na + ] Increases in Body Fluids Sensed by Central Na x Induce Sympathetically Mediated Blood Pressure Elevations via H + -Dependent Activation of ASIC1a ",

abstract = " Nomura et al. report the neural mechanisms for NaCl-induced sympathetically activated blood pressure increases. [Na + ] sensing by Na x in the OVLT and subsequent ASIC1a activation in OVLT(→PVN) neurons by H + released from Na x -positive glial cells are primary steps in this process. ",

keywords = "ASIC channel, CSF, Na channel, OVLT, PVN, blood, blood pressure, body fluid, salt-sensitive hypertension, sodium concentration",

author = "Kengo Nomura and Hiyama, {Takeshi Y.} and Hiraki Sakuta and Takashi Matsuda and Lin, {Chia Hao} and Kenta Kobayashi and Kazuto Kobayashi and Tomoyuki Kuwaki and Kunihiko Takahashi and Shigeyuki Matsui and Masaharu Noda",

note = "Funding Information: We thank K. Deisseroth (Stanford University) for the hChR2(H134R) gene and eNpHR3.0 gene. We also thank F. Vaccarino (Yale University) for the hGFAP-CreER T2 knockin mouse. We thank S. Miura, T. Hashimoto, and Y. Isoshima for their technical assistance and A. Kodama for her secretarial assistance. This work was supported by MEXT/JSPS KAKENHI (grant numbers 24220010 to M.N. and 26893324 and 16K18998 to K.N.), Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency ( CREST , JST to M.N., grant number JPMJCR1754 ), the Japan Agency for Medical Research and Development ( AMED PRIME to T.Y.H., grant number JP17gm0810014 ), the Ichiro Kanehara Foundation (to M.N.), the Takeda Science Foundation (to M.N. and T.Y.H.), the Salt Science Research Foundation (to T.Y.H.), and a Sasakawa Scientific Research Grant from the Japan Science Society (to K.N). This work was also supported by the Cooperative Study Program of the National Institute for Physiological Sciences. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Noda, Masaharu

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