N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: Substituent effects on subtype selectivity

Hiroko Sano; Tomomi Noguchi; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.52.1021

N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: Substituent effects on subtype selectivity

Hiroko Sano, Tomomi Noguchi, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.

Original language	English
Pages (from-to)	1021-1022
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	8
DOIs	https://doi.org/10.1248/cpb.52.1021
Publication status	Published - Aug 2004

Keywords

Cyclooxygenase (COX)
N-substituted phenylphthalimide
Selectivity
Thalidomide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.52.1021

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abstract = "Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.",

keywords = "Cyclooxygenase (COX), N-substituted phenylphthalimide, Selectivity, Thalidomide",

author = "Hiroko Sano and Tomomi Noguchi and Aya Tanatani and Hiroyuki Miyachi and Yuichi Hashimoto",

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AU - Sano, Hiroko

AU - Noguchi, Tomomi

AU - Tanatani, Aya

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

PY - 2004/8

Y1 - 2004/8

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KW - Cyclooxygenase (COX)

KW - N-substituted phenylphthalimide

KW - Selectivity

KW - Thalidomide

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N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: Substituent effects on subtype selectivity

Abstract

Keywords

ASJC Scopus subject areas

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