N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide

Substituent effects on subtype selectivity

Hiroko Sano, Tomomi Noguchi, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.

Original languageEnglish
Pages (from-to)1021-1022
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Lead compounds
Thalidomide
Cyclooxygenase Inhibitors
Prostaglandin-Endoperoxide Synthases
Derivatives
Phenylhomophthalimide
N-phenylphthalimide
Lead

Keywords

  • Cyclooxygenase (COX)
  • N-substituted phenylphthalimide
  • Selectivity
  • Thalidomide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide : Substituent effects on subtype selectivity. / Sano, Hiroko; Noguchi, Tomomi; Tanatani, Aya; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 8, 08.2004, p. 1021-1022.

Research output: Contribution to journalArticle

Sano, Hiroko ; Noguchi, Tomomi ; Tanatani, Aya ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide : Substituent effects on subtype selectivity. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 8. pp. 1021-1022.
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