Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.
- Cyclooxygenase (COX)
- N-substituted phenylphthalimide
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry