N-phenylphthalimide-type cyclooxygenase (COX) inhibitors derived from thalidomide: Substituent effects on subtype selectivity

Hiroko Sano, Tomomi Noguchi, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.

Original languageEnglish
Pages (from-to)1021-1022
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 1 2004

Keywords

  • Cyclooxygenase (COX)
  • N-substituted phenylphthalimide
  • Selectivity
  • Thalidomide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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