Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report

Tomohiro Habu, Junichi Sou, Tomohiro Toji, Kazuhiko Shien, Eito Niman, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. We report a surgical case of 51-year-old woman with myoepithelioma occurring in the posterior mediastinum that harbored the Ewing sarcoma breakpoint region1 (EWSR1) gene rearrangement. To the best of our knowledge, this is the first report of a myoepithelioma occurring in the posterior mediastinum. In this case, the patient underwent the thoracoscopic surgery for a diagnostic tumorectomy and was diagnosed as myoepithelioma based on the following immunohistological findings. Considering the unusual location, we additionally performed a cytogenetic analysis to confirm the presence of the EWSR1 gene rearrangement, which is a genetic characteristic of myoepithelioma.

Original languageEnglish
Pages (from-to)851-854
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume48
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Myoepithelioma
Ewing's Sarcoma
Mediastinum
Gene Rearrangement
Thoracic Cavity
Thoracoscopy
Cytogenetic Analysis
Human Mammary Glands
Salivary Glands
Cytogenetics

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement : a case report. / Habu, Tomohiro; Sou, Junichi; Toji, Tomohiro; Shien, Kazuhiko; Niman, Eito; Namba, Kei; Sato, Hiroki; Yamamoto, Hiromasa; Sugimoto, Seiichiro; Yamane, Masaomi; Toyooka, Shinichi.

In: Japanese Journal of Clinical Oncology, Vol. 48, No. 9, 01.09.2018, p. 851-854.

Research output: Contribution to journalArticle

@article{26fcbad4a7ba4fb086a23a541ea608bc,
title = "Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report",
abstract = "Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. We report a surgical case of 51-year-old woman with myoepithelioma occurring in the posterior mediastinum that harbored the Ewing sarcoma breakpoint region1 (EWSR1) gene rearrangement. To the best of our knowledge, this is the first report of a myoepithelioma occurring in the posterior mediastinum. In this case, the patient underwent the thoracoscopic surgery for a diagnostic tumorectomy and was diagnosed as myoepithelioma based on the following immunohistological findings. Considering the unusual location, we additionally performed a cytogenetic analysis to confirm the presence of the EWSR1 gene rearrangement, which is a genetic characteristic of myoepithelioma.",
author = "Tomohiro Habu and Junichi Sou and Tomohiro Toji and Kazuhiko Shien and Eito Niman and Kei Namba and Hiroki Sato and Hiromasa Yamamoto and Seiichiro Sugimoto and Masaomi Yamane and Shinichi Toyooka",
year = "2018",
month = "9",
day = "1",
doi = "10.1093/jjco/hyy100",
language = "English",
volume = "48",
pages = "851--854",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement

T2 - a case report

AU - Habu, Tomohiro

AU - Sou, Junichi

AU - Toji, Tomohiro

AU - Shien, Kazuhiko

AU - Niman, Eito

AU - Namba, Kei

AU - Sato, Hiroki

AU - Yamamoto, Hiromasa

AU - Sugimoto, Seiichiro

AU - Yamane, Masaomi

AU - Toyooka, Shinichi

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. We report a surgical case of 51-year-old woman with myoepithelioma occurring in the posterior mediastinum that harbored the Ewing sarcoma breakpoint region1 (EWSR1) gene rearrangement. To the best of our knowledge, this is the first report of a myoepithelioma occurring in the posterior mediastinum. In this case, the patient underwent the thoracoscopic surgery for a diagnostic tumorectomy and was diagnosed as myoepithelioma based on the following immunohistological findings. Considering the unusual location, we additionally performed a cytogenetic analysis to confirm the presence of the EWSR1 gene rearrangement, which is a genetic characteristic of myoepithelioma.

AB - Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. We report a surgical case of 51-year-old woman with myoepithelioma occurring in the posterior mediastinum that harbored the Ewing sarcoma breakpoint region1 (EWSR1) gene rearrangement. To the best of our knowledge, this is the first report of a myoepithelioma occurring in the posterior mediastinum. In this case, the patient underwent the thoracoscopic surgery for a diagnostic tumorectomy and was diagnosed as myoepithelioma based on the following immunohistological findings. Considering the unusual location, we additionally performed a cytogenetic analysis to confirm the presence of the EWSR1 gene rearrangement, which is a genetic characteristic of myoepithelioma.

UR - http://www.scopus.com/inward/record.url?scp=85051817929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051817929&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyy100

DO - 10.1093/jjco/hyy100

M3 - Article

C2 - 30053180

AN - SCOPUS:85051817929

VL - 48

SP - 851

EP - 854

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 9

ER -