Myocardial mechanical restitution and potentiation partly underlie alternans decay of postextrasystolic potentiation: Simulation

Satoshi Mohri, Junichi Araki, Takeshi Imaoka, Gentaro Iribe, Masaki Maesako, Juichiro Shimizu, Hiromi Matsubara, Tohru Ohe, Masahisa Hirakawa, Hiroyuki Suga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have reported that the postextrasystolic potentiation (PESP) decays in alternans or monotonically, respectively, depending on whether the first postextrasystolic beat interval has a compensatory pause or not, in the canine left ventricle. To get better mechanistic insight into the alternans PESP decay, we hypothesized that the myocardial mechanical restitution and potentiation could partly account for both types of PESP decay. To test this hypothesis, we simulated PESP decay on a computer using a documented equation combining myocardial mechanical restitution and potentiation. We changed the first postextrasystolic beat interval after a fixed extrasystolic beat interval without changing regular and other postextrasystolic beat intervals. The simulated PESP decayed in alternans or monotonically as a function only of the first postextrasystolic beat interval. Thus, the myocardial mechanical restitution and potentiation could partly account for both alternans and monotonic decay of PESP. We conclude that myocardial mechanical restitution and potentiation may partly underlie the initial two alternating beats, the first beat being the most potentiated and the second beat being the most depressed, of alternans PESP decay in the canine heart.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalHeart and Vessels
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Calcium
  • Compensatory pause
  • Extrasystole
  • Force-interval relation
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Mohri, S., Araki, J., Imaoka, T., Iribe, G., Maesako, M., Shimizu, J., Matsubara, H., Ohe, T., Hirakawa, M., & Suga, H. (1999). Myocardial mechanical restitution and potentiation partly underlie alternans decay of postextrasystolic potentiation: Simulation. Heart and Vessels, 14(2), 82-89. https://doi.org/10.1007/BF02481747