Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice

Afia Khatun, Masashi Sakurai, Yusuke Sakai, Masato Tachibana, Naoya Oohara, Masahiro Morimoto

Research output: Contribution to journalArticle

Abstract

It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues produce α-defensin, an anti-bacterial peptide. We investigated in this study whether eosinophils reacting to mycobacteria produce α-defensin in mice and whether it can be used as a model. We showed that mycobacterial infection induced blood eosinophilia and infiltration of α-defensin producing eosinophils that to surround mycobacteria at the site of infection. These findings were usually seen during human mycobacterial infection. We established a good model to study host defense mechanism against mycobacteria through α-defensin via eosinophils.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalThe Journal of veterinary medical science
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 25 2019

Fingerprint

Defensins
mycobacterial diseases
eosinophilia
Eosinophilia
eosinophils
Eosinophils
Mycobacterium
mice
Infection
antimicrobial peptides
defense mechanisms
inflammation
Inflammation
Peptides
blood
infection

Keywords

  • animal model
  • eosinophil
  • mycobacteria
  • α-defensin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice. / Khatun, Afia; Sakurai, Masashi; Sakai, Yusuke; Tachibana, Masato; Oohara, Naoya; Morimoto, Masahiro.

In: The Journal of veterinary medical science, Vol. 81, No. 1, 25.01.2019, p. 138-142.

Research output: Contribution to journalArticle

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