Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice

Jun Chen, Taku Kaitsuka, Rika Fujino, Kimi Araki, Kazuhito Tomizawa, Tetsuro Yamamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ribosomal protein S19 (RP S19) possesses ribosomal function as RP S19 monomer and extraribosomal function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88). We have generated a Gln137Glu-RP S19 knock-in (KI) mouse, which is shown to possess the weakened extraribosomal function of RP S19. Because whether the extraribosomal function of RP S19 has a role in brain function had been unclear, we performed behavioral analysis on these mice and demonstrated that KI mice displayed an increased grooming behavior during open-field test and elevated plus maze test and an enhanced freezing behavior in contextual fear conditioning test. These results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalNeuroscience Letters
Volume629
DOIs
Publication statusPublished - Aug 26 2016
Externally publishedYes

Fingerprint

Grooming
Mutation
Anaphylatoxin C5a Receptor
ribosomal protein S19
Freezing
Fear
Anxiety
Ligands
Brain

Keywords

  • Anxiety-like behavior
  • Complement system
  • Extraribosomal function
  • Fear memory
  • Grooming behavior
  • Ribosomal protein S19

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. / Chen, Jun; Kaitsuka, Taku; Fujino, Rika; Araki, Kimi; Tomizawa, Kazuhito; Yamamoto, Tetsuro.

In: Neuroscience Letters, Vol. 629, 26.08.2016, p. 221-226.

Research output: Contribution to journalArticle

Chen, Jun ; Kaitsuka, Taku ; Fujino, Rika ; Araki, Kimi ; Tomizawa, Kazuhito ; Yamamoto, Tetsuro. / Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. In: Neuroscience Letters. 2016 ; Vol. 629. pp. 221-226.
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