Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility

Chizuru Sogawa, Yasuhiro Fujiwara, Satoshi Tsukamoto, Yuka Ishida, Yukie Yoshii, Takako Furukawa, Tetsuo Kunieda, Tsuneo Saga

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: C-type natriuretic peptide (CNP) signaling through its receptor natriuretic peptide receptor B (NPR-B) is a key molecule for mammalian reproduction, and known to play important roles in female fertility. However, the function of these peptides in mouse male reproduction remains largely unknown. To determine the role of CNP/NPR-B signaling in male reproduction we investigated phenotype of Npr2-deficient short-limbed-dwarfism (Npr2slw/slw) mice, which have been shown to have gastrointestinal (GI) abnormalities.Findings: In homozygous Npr2slw/slw mice, spermatogenesis is developmentally delayed at both 2 and 4 weeks of age, with vacuolation and degenerating apoptotic germ cells being observed at 3 weeks age. However, the adult Npr2slw/slw mice exhibited apparently normal spermatogenesis, albeit with some aberrant spermatids, suggesting that developmental delay was overcome. In addition, the adult Npr2slw/slw mice showed abnormal penile morphology (paraphimosis).Conclusions: The potential role of CNP signaling via the NPR-B receptor in male fertility appears to be mediated not through germ-cell development, but may be through maintenance of normal penile function.

Original languageEnglish
Article number64
JournalReproductive Biology and Endocrinology
Volume12
Issue number1
DOIs
Publication statusPublished - Jul 10 2014

Fingerprint

C-Type Natriuretic Peptide
Fertility
Phenotype
Reproduction
Spermatogenesis
Germ Cells
Paraphimosis
Dwarfism
Spermatids
Maintenance
atrial natriuretic factor receptor B
atrial natriuretic factor receptor C
Peptides

Keywords

  • cGMP
  • CNP
  • Infertility
  • NPR-B
  • Paraphimosis
  • SLW mouse
  • Smooth muscle
  • Spermatogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility. / Sogawa, Chizuru; Fujiwara, Yasuhiro; Tsukamoto, Satoshi; Ishida, Yuka; Yoshii, Yukie; Furukawa, Takako; Kunieda, Tetsuo; Saga, Tsuneo.

In: Reproductive Biology and Endocrinology, Vol. 12, No. 1, 64, 10.07.2014.

Research output: Contribution to journalArticle

Sogawa, Chizuru ; Fujiwara, Yasuhiro ; Tsukamoto, Satoshi ; Ishida, Yuka ; Yoshii, Yukie ; Furukawa, Takako ; Kunieda, Tetsuo ; Saga, Tsuneo. / Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility. In: Reproductive Biology and Endocrinology. 2014 ; Vol. 12, No. 1.
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